人膀胱癌细胞nm23蛋白表达量与丝裂霉素抗药指数之间的相关性研究  

Study on relationship between expression of nm23 protein and resistance of mitomycin C for human bladder carcinoma cells

作　　者：王毅[1] 罗志刚[1] 刘水清[1] 龙炳衡[1] 魏建华[1] 秦国庆[1] 刘京平[1] 陈仙[1] 李建军[1] 何岳清[1] 曹建国[2] 

机构地区：[1]南华大学附二医院泌尿外科,湖南衡阳421001 [2]南华大学肿瘤研究所

出　　处：《中国肿瘤临床与康复》2003年第3期196-198,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的 探讨膀胱癌细胞nm23蛋白表达量与丝裂霉素药物敏感性之间的相关性。为临床膀胱移行细胞癌治疗方案选择提供理论依据。方法 对32例临床病理诊断为膀胱移行细胞癌标本采用S-P免疫组化和图像分析技术检测细胞的nm23蛋白表达量;同时采用MTT法测定膀胱癌细胞对丝裂霉素的药物敏感性。结果 膀胱癌nm23表达量与MMC抗药指数相关,相关指数为0.890(P<0.001)。结论 膀胱癌nm23蛋白表达量与MMC抗药指数呈正相关。Objective To research on relationship between expression of nm23 protein and resistance of mitomycin C(MMC) for human bladder carcinoma cells. Methods Expression of nm23 protein in 32 specimens of human bladder carcinoma were analyzed by S-P immunohistochemical method.The MTT assay was used to test che-mosensitivity of the human bladder carcinoma cells to mitomycin C. Results Expression of nm23 protein in difference of the human bladder carcinoma specimens are positive, the positive rate is 75% (12/16) .There was positive relationship between expression of nm23 protein and resistance index of mitomycin C for human bladder carcinoma cells ( r = 0.890, P < 0.001) . Conclusion There is positive relationship between expression of nm23 protein and resistance of mitomycin C for human bladder carcinoma cells.

关 键 词：膀胱癌 NM23蛋白 丝裂霉素 药物敏感性 表达量 相关性 

分 类 号：R737.14[医药卫生—肿瘤]