胃癌及癌前病变组织中p53、c-erbB-2基因表达  

The expression of p53 and c-erbB-2 protein in gastric cancer and precancerous lesions

作　　者：金小萍[1] 齐洁敏[2] 

机构地区：[1]承德医学院附属医院病理科,河北承德067000 [2]承德医学院病理教研室,河北承德067000

出　　处：《河北医学》2003年第6期507-508,共2页Hebei Medicine

摘　　要：目的 :探讨p5 3、c -erbB - 2基因表达与胃癌及癌前病变生物学行为之间的关系。方法 :采用免疫组化ABC法检测胃粘膜病变中的p5 3、c -erbB - 2蛋白表达。结果 :慢性浅表性胃炎组织中p5 3、c -erbB - 2蛋白无表达 ;慢性萎缩性胃炎p5 3、c -erbB - 2蛋白表达率分别为 10 %、2 0 % ;早期胃癌组织中分别为 5 0 %、4 1% ;进展期胃癌中的表达率分别为 73%、76 .7%。结论 :p5 3、c -erbB -Objective: To study the relationship between the expressions of p53and c-erbB-2 genes and the biological behaviors of stomach cancer and precancerous lesions. Methods: Expressions of p53and c-erbB-2 genes were detected in gastric mucosa lesions by immunohistochemical ABC method . Results: p53and c-erbB-2 genes expression were not shown in the tissues of chronic superficial gastritis ;In the chronic atrophic gastritis ,the positive rates were 10%and 20% and 20% respectively ; In the tissues of early gastric cancer , the positive rates were 50% and 41% respectively ;In the tissues of advanced gastric cancer ,the positive rates were 73% and 76.7% respectively. Conclusion: The cooperative effects of p53and c-erbB-2 genes involve in cancer of gastric mucosa .

关 键 词：胃癌 癌前病变组织 P53 C-ERBB-2 基因表达 

分 类 号：R735.2[医药卫生—肿瘤]