血管内皮生长因子在结核性和癌性胸腔积液中的表达  

The expression of Vascular Endothelial Growth Factor in tuberculous and malignant pleural effusions

作　　者：张秀琴[1] 吕喜英[1] 华正祥[1] 陈伟红[1] 

机构地区：[1]承德医学院附属医院,河北承德067000

出　　处：《河北医学》2003年第6期513-514,共2页Hebei Medicine

摘　　要：目的 :探讨可溶性血管内皮生长因子 (SolableVascularEndothelialGrowthFactor ,sVEGF)在结核性及癌性胸腔积液鉴别诊断中的价值。方法 :采用酶联免疫吸附 (ELISA)法检测了 4 0例结核性和 4 0例癌性胸腔积液患者胸液中的sVEGF水平。结果 :癌性胸液内sVEGF水平 170 2 .5 1± 4 90 4 .2 0pg/ml明显高于结核性胸液内sVEGF水平 4 5 2 .5 4± 74 3.0 1pg /ml,(P <0 .0 0 1)。结论 :癌性胸腔积液内的sVEGF水平显著高于结核性胸腔积液内的水平 ,但有交叉重叠现象 。Objective: The purpose of this study was to evaluate the valuable of Solable Vascular Endothelial Growth Factor(sVEGF) in tuberculous and malignant pleural effusions. Methods: Using a sandwich enzyme-linked immunoadsorbent assay, sVEGF was measured in malignant (n=40) and in tuberculous (n=40) pleural effusions. Result: SVEGF levels (1702.51±4904.20pg/ml) in malignant pleural effusions were significantly higher than those (452.54±743.01pg/ml) in tuberculous pleural effusions. Conclusion: Pleural sVEGF levels in patients with malignant effusions were significantly higher than tuberculous effusions. But there was many repeation between them, so further studies were needed to determine the clinical value of sVEGF as a tumor marker.

关 键 词：血管内皮生长因子 结核性 癌性 胸腔积液 表达 

分 类 号：R730.4[医药卫生—肿瘤]