新兵强化训练致胃黏膜病变的防治研究  

Prevention and treatment of gastric mucosal lesions in armed police recruits in intensified training

作　　者：胡宝春[1] 马凌 刘巧玲[1] 杨艳[1] 房广英[3] 李华富[1] 向海燕[1] 

机构地区：[1]武警广东总队医院二内科 [2]武警广东总队医院医务处,广州510507 [3]武警广东总队医院病理科,广州510507

出　　处：《武警医学》2003年第7期402-405,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的 研究新兵强化训练对受训士兵胃黏膜的影响。方法 观察61例不同分组的新兵训练前后胃十二指肠黏膜的内镜表现、组织学改变、幽门螺杆菌(Helicobacter pylori,HP)感染情况和血清促胃液素、胰岛素及皮质醇含量的变化。结果 新兵强化训练后有上消化道症状的人数增多,且症状有一定程度加重,观察组与预防组之间差异无显著性意义(P>0.05);胃镜下观察胃十二指肠黏膜,训练前观察组和预防组分别有80.5％和80.0％发现浅表性炎症以上的病变,训练后有病变者增加到92.7％和95.0％,训练前后两组之间差异均无显著性意义(P>0.05);训练后观察组的糜烂性炎症人数与训练前比较增加(P<o.05);而预防组强化训练前后黏膜病变差异无显著性意义(P>0.05);训练后HP感染率从42.6％升高到55.7％(P>0.05);训练后血清胰岛素和皮质醇水平较训练前明显升高(P<0.05和P<0.01),促胃液素升高但训练前后比较,差异无显著性意义(P>0.05)。结论 新兵强化训练可造成受训士兵胃黏膜一定程度的损伤,应激可导致内分泌激素水平变化并与胃黏膜损伤有关;预防性药物治疗有助于减少胃黏膜损伤的发生。Objective To study the prevention and treatment of the gastric mucosal lesions in armed police recruits in intensified training. Methods Sixty - one recruits were investigated for symptoms upper digestive tract and gastric mucosal lesions by gastroscopy and biopsy before and after one-month military training. Helicobacter pylori, serum gastrin, insulin and corticol were observed by immunoradioassay.The subjects were divided randomly into an observation groups ( n = 41) and a prevention group ( n = 20), and the latter group was administered orally ranitidine (150 mg, bid) and sucralfate (l.Og, tid) during the period of training. Results After training, the recruits with symptoms of upper digestive tract increased in number,and the symptoms were aggravated, but there was no significantly difference between the two groups ( P > 0.05) .Endoscopically,80.5% in observation group and 80.0% in prvention group were found to have superficial gastritis or erosive gastntis before training, while 92.7% in observation group and 95.0% in prevention group were found to have the gastric mucosal inflammation after training, the differences being not significant between the two groups both before and after training ( P > 0.05). Compared with those before training, the cases of erosive gastritis increased in number in observation group ( P < 0.05), while such was not the case in prevention group ( P > 0.05). The infective rate of Helicobacter pylori was increased from 42.6 % before training to 55.7 % after training, with no significant difference ( P > 0.05). The levels of serum gastrin, insulin and cortisol after training were much higher than those before training ( P > 0.05) for gastrin, P <0.05 for insulin, and P <0.01 for cortisol, respectively).Conclusion Recruits may suffer from gastric mucosal lesions during military training, which is closely related to the high levels of endocrine hormones in serum because of stress. Administration of drugs preventively is helpful to reducing gastric mucosal lesions during training of recr

关 键 词：新兵 强化训练 胃黏膜病变 组织学改变 幽门螺杆菌感染 预防 治疗 胃镜 

分 类 号：R573[医药卫生—消化系统]