调肝颗粒剂提取物干燥工艺的研究  

Study on drying technology of Tiaogan Granules

作　　者：王地[1] 贾富霞[1] 关怀[1] 李江[1] 

机构地区：[1]首都医科大学中医药学院,北京100013

出　　处：《中成药》2003年第8期617-618,共2页Chinese Traditional Patent Medicine

摘　　要：目的 :优选调肝颗粒剂 (黄芪 ,丹参等 )提取液的干燥方法。改善药液在喷雾干燥过程中的粘壁现象。方法 :用干燥时间、干燥温度及其对干燥物质的影响 ,评价不同的干燥方法 ;以喷雾干燥过程中药粉粘壁量、药粉制粒后的吸湿性为指标 ,考察不同辅料对喷雾干燥的影响 ,并优选辅料品种及用量。结果 :喷雾干燥法所得颗粒性状最优 ;β 环糊精和乳糖均有改善药液粘壁的作用。结论 :喷雾干燥法优于其它干燥方法 ;药液中加入 3～ 5 % β 环糊精可有效改善喷雾干燥过程中的粘壁程度。Objective: To seek the optimum technology of drying and to solve the problem of powder sticking clump. Methods : On the basis of major drying condition, such as duration of drying, temperature of drying, evaluating different drying technology; On the basis of the quantity of the powder sticking on the wall and the hygroscopicity of one, investigating different excipients how to affect the spray drying. Seeking the optimum kinds and quantity of excipients. Results : The best properties of the granules are from the spray drying process. β-cyclodextrin and lactose have the effects on solving the powder sticking on the wall. Conclusion : The spray drying process is the optimum one. Adding 3～5 percent of β-cyclodextrin has an effect on improving the phenomenon of powder sticking on the wall in process of the spray drying.

关 键 词：干燥工艺 喷雾干燥 β—环糊精 调肝颗粒剂 

分 类 号：R283.6[医药卫生—中药学]