黄酮—环糊精包合作用的热力学研究  

Study on Inclusion Behavior of Flavonoids with Cyclodextrin by Thermodynamic Method

作　　者：双少敏[1] 徐文祥[1] 张国梅[1] 董川[1] 潘景浩[1] 

机构地区：[1]山西大学化学化工学院,山西太原030006

出　　处：《山西大学学报（自然科学版）》2003年第3期196-199,共4页Journal of Shanxi University(Natural Science Edition)

基　　金：国家自然科学基金(20275022);山西省自然科学基金(20011010)

摘　　要：利用荧光法研究了四种黄酮类化合物与β-环糊精(β-CD)及其衍生物的包合行为,测定了包合物的包合比和包合形成常数,从热力学的角度详细探讨了影响包合过程的因素.结果表明,β-CD衍生物比母体有更强的包合能力,包合计量比为1∶1,包合过程的热力学函数△G<0,△H<0,△S为负值或较小的正值,由此说明包合的驱动力主要来自于分子内识别的焓变.另外,包合过程存在焓-熵补偿效应,所得体系的补偿温度为276K.The inclusion behavior of flavonoids (rutin, qucertin, morine and hydroxyethyl-rutin) withβ-CD and its derivative (HP-β-CD,CM-β-CD ) were studied systematically by using fluorimetry and thermodynamic method. The stoichiometry and the formation constants of inclusion complexes were determined. Affect factors such as CD concentration and temperature were discussed in detail. The results showed that the stoichiometry is 1∶1 and CD derivatives have the stronger binding capacity. According to the thermodynamic parameters(△G°<0,△H°<0,△S°<0 or △S°>0),the inclusion reactions belong to exothermic ones. The thermodynamic of complex formation displays enthalpy---entropy compensation effect, and the enthalpy-entropy compensation temperature of this system is 276K.

关 键 词：黄酮 环糊精 包合作用 热力学 包合模型 荧光法 药物学 超分子化学 药物载体 

分 类 号：TQ460.4[化学工程—制药化工] O642.1[理学—物理化学]