15例甲状腺间变癌临床病理及免疫组化分析  

A Clinicopathological and Immunohistochemical Analysis of15Cases with Anaplatic Thyroid Carcinoma

作　　者：陈燕坪[1] 许磊[1] 蔡晓雯[1] 

机构地区：[1]福建省肿瘤医院,福建福州350014

出　　处：《肿瘤学杂志》2003年第4期218-219,共2页Journal of Chinese Oncology

摘　　要：[目的]探讨甲状腺间变癌的临床病理特征和免疫组化结果的意义。[方法]光镜观察和免疫组织化学SP法检测15例甲状腺间变癌。[结果]甲状腺间变癌的病理分型为梭形细胞型、巨细胞型和混合细胞型。15例中免疫组化阳性表达率分别是:Vimentin86.6%(13/15)、CK73.3%(11/15)、CEA60.0%(9/15),CD686.6%(1/15);TG和降钙素均为阴性。2例伴有乳头状癌其中Vimentin和CK均阳性;1例伴破骨样巨细胞CD68阳性。[结论]甲状腺间变癌是上皮源性、恶性度高的肿瘤。熟悉其形态特征,结合免疫组化对诊断甲状腺间变癌具有重要意义。To explore the clinical pathological and immunohistochemical characteristics of anaplastic thyroid carcinoma.Fifteen cases with anaplastic thyroid carcinoma were studied by light microscopy and immunohistochemistry.The pathological types in15cases were composed of giant,spindle,and mixed cells.The positive rates of Vimentin,CK,CEA and CD68were86.6%(13/15),73.3%(11/15),60%(9/15)and6.6%(1/15)respectively.All cases were negative for TG and Calcitonin.Two cases of anaplastic thyoid carcinoma associated with papillary thyroid carcinoma expressed CK and Vimentin.One case associated with osteoclast-like giant cells expressed CD68.[Conclusion]Anaplastic thyroid carcinoma is a high-grade carcinoma that originates from epithelium to be familiar with morphological characteristic and immunohistochemistry plays an important role in the diagnosis for anaplastic thyroid carcinoma.

关 键 词：间变癌 甲状腺 病理分型 免疫组化 

分 类 号：R730.2[医药卫生—肿瘤] R736.1[医药卫生—临床医学]