^(103)Pd放射性支架持续照射犬胆管的放射性损伤的实验研究  

Radiation injury of canine bile duct induced by ^(103) Pd metal stent

作　　者：何贵金[1] 张申众[2] 金永柏[3] 曹明洲[3] 姜维国[1] 戴显伟[1] 高红[4] 蒋涛[4] 马凯[1] 

机构地区：[1]中国医科大学第二临床学院普外一科,沈阳110004 [2]沈阳第十人民医院普外科 [3]中国科学院沈阳金属研究所 [4]中国医科大学儿外实验室,沈阳110004

出　　处：《中华放射医学与防护杂志》2003年第3期178-179,共2页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的　寻找动物胆管金属内支架植入方法 ,观察动物胆管植入1 0 3 Pd放射性支架 ,胆管腔内照射的放射性损伤。方法　实验动物为雄性健康杂种犬 ,体重 1 5～ 2 0kg。麻醉下经手术植入1 0 3 Pd放射性金属支架于犬的胆管腔内 ,1 0 3 Pd的放射性活度分别为 1 2 5× 1 0 4kBq、1 6 6× 1 0 4kBq、2 2 2× 1 0 4kBq、2 5 9× 1 0 4kBq、2 9 6× 1 0 4kBq和 3 7× 1 0 5kBq ,植入后 30d取出1 0 3 Pd放射性金属支架和胆管 ,后者经组织切片HE染色 ,光镜下进行放射性损伤的评价。结果　放射性活度为 1 2 5× 1 0 4kBq ,光镜下可观察到黏膜损伤 ;放射性活度为 2 2 2× 1 0 4kBq时胆管放射性损伤达肌层 ;放射性活度为3 7× 1 0 5kBq时放射性损伤达胆管壁外膜 ,出现胆管穿孔。根据不同放射性活度照射后 ,胆管的放射性损伤的放射性活度效应曲线得出 ,ED50 为 2 8 2× 1 0 4kBq。结论　1 0 3 Pd金属支架胆管腔内近距离照射有明显的剂量 效应关系 ,为该放射性支架应用于临床治疗胆管良。Objective\ To assess radiation injury of dog bile duct induced by 103 Pd metal stent. Methods\ Hybrid dogs with body weight form 15 to 20 kg were used. 103 Pd metal stent was implanted into the common bile duct under anaesthesia,and the irradiation doses by 103 Pd were 12 5×10 4 kBq,16 6×10 4 kBq,22 2×10 4 kBq,25 9×10 4 kBq,29 6×10 4 kBq and 3 7×10 5 kBq,respectively. Results\ Radiation injury on the mucosa of the bili duct was observed in 12 5×10 4 kBq group,and the damage extended to the muscular layer in 22 2×10 4 kBq group.Perforation of the bile duct was observed in 3 7×10 5 kBq group.The dose\|response curve of radiation injury at different doses of intra\|biliary metal stent 103 Pd showed the effective dose (ED 50 ) to be 28 2×10 4 kBq. Conclusion\ There is an obvious dose response relationship for in the 103 Pd metal stent.our result is unimportant theoretical basis for application of 103 Pd metal stent to clinical treatment of biliary cancer.\;

关 键 词：^103Pd放射性支架胆管腔内照射治疗 放射性损伤 辐射剂量 效应 

分 类 号：R730.55[医药卫生—肿瘤] R818.74[医药卫生—临床医学]