双氯芬酸胆碱滴眼液治疗化学性炎症实验研究  

The anti-inflammatory effects of diclofenac acid-choline eyedrops on rabbit eye of chemical traumatic inflammation.

作　　者：张小莉[1] 闫素清[2] 刘洁[2] 李逊霞[1] 刘利娥[2] 韩立瑞[3] 

机构地区：[1]郑州大学科研处,郑州450052 [2]郑州大学公共卫生学院卫生化学教研室 [3]郑州大学药学系

出　　处：《眼外伤职业眼病杂志》2003年第6期367-368,共2页Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries

摘　　要：目的 探讨不同浓度双氯芬酸胆碱(diclofenac acid-choline,DAC)滴眼液的抗炎效果。方法 新西兰大白兔36只,按用药浓度随机分为3组,以斑蝥酊为刺激剂,造成化学性眼外伤的炎症模型。每组家兔均为右眼滴入此滴眼液为用药眼,左眼滴入生理盐水为对照眼。观察各组用药眼对角膜、虹膜、结膜化学性外伤性炎症的治疗效果。结果 0.50g/L、1.00g/L和2.00g/L 3种浓度的双氯芬酸胆碱滴眼液消除炎症反应积分评价,用药眼与对照眼差异有显著意义(P<0.05),1.00g/L和2.00g/L与0.50g/L滴眼液组之间比较差异有显著意义(P<0.05),1.00 g/L与2.00g/L组之间差异无显著意义(P>0.05)。结论 1.00 g/L双氯芬酸胆碱滴眼液可作为临床应用较适宜的浓度的参考。Objective To explore the anti-inflammatory effects of diclofenac acid-choline eyedops in different concentration. Methods A total fo 36 New Zealand rabbits were randomly divided into 3 groups. The eye in- flammatory modles were made by chemical inflammation using Chinese blister betel tincture. The right eyes were droped with diclofenac aeid-choline eyedrops in the concentration of 0.05,1.00,2.00 g/L and the left eyes were droped with normal saline respectively. The treatment effects of different concentrations for the inflammation of the cornea, iris and conjunctivitis were evaluated. Results The total scores which diclofenac acid-choline eyedrops in 0.05 g/L, 1.00 g/L and 2.00 g/L and 2.00 g/L in alleviating the strength of inflammation were evaluated: There were very significant differences between the right eyes which droped with diclofenac acid-choline and the left eyes which didn't(P < 0.05) ;there were also some significant differences between the concentration of 1 .00 g/L or 2.00 g/L and the concentration of 0.05 g/L( P < 0.05);There were not significant differences between 1.00 g/L and 2.00 g/L( P > 0.05). Conclusion The clinical applied concentration of diclofenac acid-choline eyedrops should be 1.00 g/L.

关 键 词：化学性炎症 眼化学伤 双氯芬酸胆碱滴眼液 治疗 实验研究 

分 类 号：R770.5[医药卫生—眼科]