水杉总黄酮对豚鼠工作心脏缺血再灌注损伤的影响  

Effects of total flavones metasequosia on ischemia reperfusion injury in guinea pig working heart

作　　者：王芳[1] 余恩欣 刘惟莞[3] 屠治本[4] 

机构地区：[1]武汉大学人民医院药学部,武汉430060 [2]湖北省药品检验所药理室,武汉430064 [3]武汉大学医学院药理学教研室,武汉430071 [4]中国科学院武汉植物研究所,武汉430074

出　　处：《中国药理学通报》2003年第8期926-928,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题No 39970 0 85

摘　　要：目的　观察水杉总黄酮对缺血再灌注损伤心肌的保护作用。方法　采用豚鼠工作心脏缺血再灌注损伤模型 ,观察水杉总黄酮对缺血再灌注损伤心肌心功能以及生化指标的影响。结果　水杉总黄酮能明显改善缺血再灌注损伤心肌的舒缩功能 ,剂量依赖性地降低冠脉流出液中肌酸磷酸激酶以及乳酸脱氢酶的活性 ,减少缺血心肌组织中丙二醛的含量。结论　水杉总黄酮对缺血再灌注损伤心肌具有保护作用 。AIM To investigate the effects of t ot al flavones metasequosia (TFM) on ischemia reperfusion injury in guinea pig work ing heart. METHODS Ischemia reperfusion injury model was used to evaluate the effects of TFM. Myocardial func tion, the content of CK、LDH and the activity of MDA were measured. RESU LT TFM improved the cardiac function, decreased the release of LDH and CK and inhibited the increase of MDA content. CONCLUSION TFM had a protective effect on ischemia reperfusion injury of myocardium which could be re lated to its inhibitory effect on lipid peroxidation.

关 键 词：水杉总黄酮 工作心脏 再灌注损伤 脂质过氧化 

分 类 号：R－332[医药卫生] R282.71