1-[2-(2,4-二氟苯基)-2,3-环氧丙基]-1H-1,2,4-三唑甲烷磺酸盐的合成  

Synthesis of 1-[2-(2,4-Difluorophenyl)-2,3-epoxypropyl]- 1 H -1,2,4-triazole Methanesulphonate

作　　者：盛春泉[1] 张万年[1] 季海涛[1] 宋云龙[1] 

机构地区：[1]第二军医大学药学院,上海200433

出　　处：《中国医药工业杂志》2003年第7期321-321,344,共2页Chinese Journal of Pharmaceuticals

基　　金：军队"十五"工程性指令课题 ( No.0 110 5 7)

摘　　要：The title compound was synthesized from 2,4 difluoro α (1 H 1,2,4 triazol 1 yl) acetophenone by phase transfer catalytic reaction with trimethyl sulfoxonium iodide. Total yield of this improved method was 42%.The title compound was synthesized from 2,4 difluoro α (1 H 1,2,4 triazol 1 yl) acetophenone by phase transfer catalytic reaction with trimethyl sulfoxonium iodide. Total yield of this improved method was 42%.

关 键 词：抗真菌药 中间体 三陛甲烷磺酸盐 合成 1-[2-(2 4-二氟苯基)-2 3-环氧丙基]-1H-1 2 4—三唑甲烷磺酸盐 间二氟苯 

分 类 号：TQ460.4[化学工程—制药化工]