阿弗菌素链霉菌突变株AV-m-481发酵产物的研究  

Fermentation Products of AV-m-481, A Mutant Strain of Streptomyces avermitilis

作　　者：叶少兵[1] 冯军[2] 赵文杰[2] 程晴华[2] 林纲[2] 

机构地区：[1]上海交通大学药学院,上海200030 [2]上海医药工业研究院,上海200040

出　　处：《中国医药工业杂志》2003年第7期325-327,共3页Chinese Journal of Pharmaceuticals

摘　　要：高产菌株 Streptomycesavermitilis AV- h- 16 9用亚硝基胍进行处理后得到了一不产阿弗菌素的突变株 AV- m-4 81,从该突变株的发酵产物中分离纯化出化合物 AV- L- 1和 AV- L- 2。质谱和核磁共振谱等测定表明它们分别为阿弗菌素 A1 a和 A2 a的糖苷配基。Streptomyces avermitilis AV h 169 was treated with NTG to give a mutant AV m 481 which produced several compounds different from natural avermectins. Two compounds among them, AV L 1 and AV L 2 were elucidated to be the aglycones of avermectin A 1a and A 2a , respectively by 1HNMR, 13 CNMR and MS.

关 键 词：阿弗菌素 链霉菌突变株 发酵 分离 结构鉴定 

分 类 号：TQ465.5[化学工程—制药化工]