Biotransformation of 14-Deacetoxy-13-oxo sinenxan A by Ginkgo Cell Cultures  

作　　者：Jun Gui DAI Meng ZHANG Min YE Wei Hua ZHU Ji Yu GUO Xiao Tian LIANG 

机构地区：[1]Institute of Materia Medica,Chinese Academy of Medical Science&Peking Union Medical College,Beijing 100050

出　　处：《Chinese Chemical Letters》2003年第8期804-806,共3页中国化学快报(英文版)

基　　金：This work is supported by the National Natural Science Foundation of China(to Jungui Dai,No.30100230).

摘　　要：Deacetoxy-13-oxo sinenxan A (1) was converted to 9a-hydroxy-13-oxo-2a, 5a, 10b-triacetoxy-4(20),11-taxadiene (2) and 10b-hydroxy-13-oxo-2a,5a,9a-triacetoxy- 4(20), 11- taxadiene (3) by Ginkgo cell suspension cultures in 45% and 15% yields, respectively.Deacetoxy-13-oxo sinenxan A (1) was converted to 9a-hydroxy-13-oxo-2a, 5a, 10b-triacetoxy-4(20),11-taxadiene (2) and 10b-hydroxy-13-oxo-2a,5a,9a-triacetoxy- 4(20), 11- taxadiene (3) by Ginkgo cell suspension cultures in 45% and 15% yields, respectively.

关 键 词：BIOTRANSFORMATION TAXANE cell suspension cultures Ginkgo biloba L. 

分 类 号：O621.33[理学—有机化学]