细胞周期蛋白依赖性激酶抑制物p27kip1在喉癌中的表达及意义  

EXPRESSION OF p27kip1 AND ITS SIGNIFICANCE IN LARYNGEAL CARCINOMA

作　　者：杜瀚[1] 陈建福[1] 李智渊[1] 王培基[1] 王群姬[1] 卢珊珊[1] 

机构地区：[1]温州医学院附属第一医院,浙江温州325002

出　　处：《肿瘤研究与临床》2003年第4期231-233,共3页Cancer Research and Clinic

摘　　要：目的 :研究 p2 7kip1在喉癌组织中的表达水平 ,探讨对喉癌患者的预后判断价值。方法 :采用免疫组化法检测 4 4例喉癌组织 p2 7kip1蛋白表达水平。结果 :本组 4 4例中 ,p2 7kip1蛋白表达阳性 31例 ,占 70 .5 % ,低表达者 2 7例 ,占 6 1.4 %。喉癌组织 p2 7kip1蛋白低表达 ;T1～ 2 级 (2 7.3% ) ,明显少于 T3～ 4 级 (72 .7% ) (P<0 .0 5 ) ;淋巴结转移组 (80 .8% ) ,明显高于无淋巴结转移组 (33.3% )(P<0 .0 5 )。结论 :细胞周期蛋白依赖性激酶抑制 p2 7kip1表达与喉癌 T分期及淋巴结转移密切相关 ,在喉癌中具有一定预后价值。Objective:To determine the prognostic value of immunohistochemical staining of p27kip1 in laryngeal carcinoma.Methods:44 paraffin embeded laryngeal carcinoma tissues were immunohistochemically stained.Results:The results showed that lower p27kip1 expression was detected in 27 cases(61.4 %).T 1～2 was evidently lower than T 3～4 (72.7 %).Those with lymph node involvement (80.8 %) was nore than those without lymph node involvement (33.3 %). Those relationship was statistically significant ( P <0.05).Conclusion:The results suggested that immunohistochemical staining of p27kip1 may be a valuable prognostic factor in laryngeal carcinoma.

关 键 词：喉肿瘤 细胞周期蛋白依赖性激酶抑制剂 预后 

分 类 号：R735.1[医药卫生—肿瘤]