成纤维细胞生长因子受体3在头颈部鳞癌中的表达及其意义  

Expressions and Significance of Fibroblast Growth Factor Receptor 3 in the Squamous Cell Carcinoma of Head and Neck

作　　者：赵明[1] 谷志远[1] 徐钢梅[1] 张银凯[1] 胡济安[1] 

机构地区：[1]浙江大学医学院附属口腔医院口腔颌面外科,杭州310006

出　　处：《口腔医学》2003年第4期211-213,共3页Stomatology

摘　　要：目的 探讨成纤维细胞生长因子受体3(FGFR3)在头颈部鳞癌中的表达状况及其与头颈部鳞癌分化程度的相关性。方法 采用免疫组化方法,检测FGFR3在正常口腔黏膜上皮和40例头颈部鳞癌(其中高分化鳞癌21例,中分化鳞癌16例,低分化鳞癌3例)中的表达状况。结果 FGFR3在头颈部鳞癌中呈阳性表达;高分化鳞癌细胞中FGFR3表达较强,低分化鳞癌细胞中FGFR3表达较弱;而角化中心则无FGFR3表达。正常口腔黏膜上皮中FGFR3呈阴性表达。结论 FGFR3可能与头颈部鳞癌的发病机制有关;FGFR3的表达状况与头颈部鳞癌分化程度有一定的相关性。Objective To study the expression of fibroblast growth factor receptor 3 (FGFR3) in the squamous cell carcinoma of head and neck (HNSCC), and to determine the correlation between the expression of FGFR3 and the differentiation level of the cancer. Methods With immunohistochemical localization, we tested the expression of FGFR3 in normal oral epthelium and 40 cases of squamous cell carcinoma of head and neck, including 21 cases of well - differentiated cancers, 16 cases of medium - differentiated cancers, and 3 cases of poorly - differentiated cancers. Results There was a significant positive expression of FGFR3 in head and neck squamous cell carcinomas. The expression of FGFR3 increased in well - differentiated squamous cells, and decreased in poorly - differentiated squamous cells in HNSCC. No staining for FGFR3 was found in the center of cornification. The normal oral epthelium showed a negative expression of FGFR3. Conclusion FGFR3 might play an important role in the carcinogenesis in the squamous cell carcinoma of head and neck, and the expression of FGFR3 was related to the differentiation level.

关 键 词：鳞癌 头颈部 成纤维细胞生长因子受体 免疫组化 

分 类 号：R739.8[医药卫生—肿瘤] R349.51[医药卫生—临床医学]