假橐吾中四对新的倍半萜结构研究  

Structure Studies of Four Pairs of New Secomacrotolides from Ligulariopsis shichuana

作　　者：高坤[1] 王文蜀[1] 贾忠建[1] 

机构地区：[1]兰州大学化学化工学院应用有机化学国家重点实验室,兰州730000

出　　处：《化学学报》2003年第7期1065-1070,共6页Acta Chimica Sinica

基　　金：国家自然科学基金(No.29972017);"有机化学创新群体"资助项目。

摘　　要：从假橐吾全草中分离得到四对新的(1/2,3/4,5/6,7/8)和一对已知的(9/10)8,9-开环艾里莫芬内酯型倍半萜.每一对均为C-8位差向异构体.它们的结构通过波谱方法阐明并通过酰化或酯化分离后得到证实.活性筛选实验表明,1/2和3/4具有细胞毒活性.From the whole plant of Ligulariopsis shichuana, four pairs of new (1/2, 3/4, 5/6 and 7/8) and one pair of known (9/10) 8,9-broken ring eremophila-7(11)-en-8,12-olides, i.e. secomacrotolides, have been isolated. All the lactone pairs are C-8 epimers. Their structures were elucidated by spectral methods, and confirmed by acylation and esterification. The experiment of anticancer activity reveals that two pairs (1/2 and 3/4) showed cytotoxic activity.

关 键 词：假橐吾 倍半萜 结构研究 差向异构体 波谱分析 植物药 抗肿瘤活性 

分 类 号：O629.6[理学—有机化学]