散发性阿尔茨海默病易患性与人类白细胞抗原基因频率的相关性(英文)  

Relationship between the susceptibility to sporadic Alzheimer's disease and the gene frequency of leukocyte antigen

作　　者：刘中霖[1] 王丽敏[1] 邢诒刚[1] 陶恩祥[1] 刘军[1] 肖颂华[1] 周道友[1] 

机构地区：[1]中山大学附属第二医院神经科,广东省广州市510120

出　　处：《中国临床康复》2003年第16期2260-2261,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的探讨人类白细胞抗原HLA-DR2,DRB1*04,DRB1*09基因频率与散发性阿尔茨海默病(SAD)的关系,试图从分子免疫遗传学角度揭示SAD的发病机制。方法SAD组44例(广州市精神病院中筛选),男11例,女33例,年龄59～91岁。正常对照组45例(中山大学附属第二医院保健科体检的自愿健康老年人),男14例,女31例,年龄61～88岁。采用序列特异性引物聚合酶链反应(PCR-SSP)技术分别测定44例SAD患者(SAD组)和45例正常老年人(对照组)的HLA-DR2,DRB1*04,DRB1*09基因频率。结果SAD患者中3种基因频数分别为25,5,16;频率分别为28.41%,5.68%,18.18%。而正常老年人中的相应基因频数分别为16,13,19;频率分别为17.78%,14.44%,21.11%。其中HLA-DR2,DRB1*04较对照组差异有显著性意义(χ2=4.002,4.187,P<0.05),DRB1*09差异无显著性意义(χ2=0.050,P>0.05)。结论HLA-DR2可能是SAD的易感基因,而HLA-DRB1*04可能对SAD的发病起到保护作用。HLA-DRB1*09与SAD发病无关联。Aim To investigate the relationship between the susceptibility to sporadic Alzheimer's disease(SAD) and the gene frequency of HLA DR2,DRB1*04 and DRB1*09 and to reveal the pathogenesis of SAD from the point of view of molecular immunogenetics.Methods The gene frequency of HLA DR2,DRB1*04 and DRB1*09 were detected separately by using sequence special primer polymerase chain reaction(PCR SSP) in 44 SAD patients and 45 healthy control subjects.Results The gene frequency of HLA DR2 allele(28.4%,OR=2.384,P< 0.05)was much higher in SAD patients than in normal subjects(17.8%) while the gene frequency of HLA DRB1*04(5.7%vs 14.4%,OR=0.313,P< 0.05)was much lower.There was no difference for the gene HLA DRB1*09 between the two groups.Conclusion HLA DR2 allele may increase the risk of the onset of SAD while HLA DRB1*04 may play a protective role in the pathogenesis of SAD.There is no correlation between HLA DRB1*09 allele and the onset of SAD

关 键 词：散发性阿尔茨海默病 人类白细胞抗原 基因频率 HLA-DR2 DRB1^＊04 DRB1^＊09 分子免疫遗传学 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R394[医药卫生—临床医学]