高频等位基因不平衡位点D6S1581与鼻咽癌的遗传易感性研究  

Studies on the relationship between D6S1581, a high frequency allele imbalance locus, and genetic susceptibility to nasopharyngeal carcinoma

作　　者：熊炜[1] 曾朝阳[1] 沈守荣[2] 李小玲[1] 李伟芳[1] 王蓉[1] 熊芳[3] 彭聪[1] 张秋红[1] 周鸣[1] 杨一新[1] 周厚德[1] 黄河[1] 李桂源[1] 

机构地区：[1]中南大学湘雅医学院肿瘤研究所,长沙410078 [2]湘雅三医院消化内科 [3]湘雅医院网络信息科

出　　处：《中华医学遗传学杂志》2003年第4期311-314,共4页Chinese Journal of Medical Genetics

基　　金：国家重点基础研究发展规划 (973)资助项目(G1 9980 51 0 0 8);国家高技术"863"计划资助项目 (2 0 0 1 AA2 2 1 0 31 ) ;国家自然科学基金 (30 1 0 0 0 2 7;30 1 0 0 2 1 7)~~

摘　　要：目的　探讨鼻咽癌高频等位基因不平衡位点 D6 S15 81及在其附近克隆的鼻咽癌相关基因FBXO30与鼻咽癌发生的关系。方法　应用基因扫描技术 ,对 12个湖南鼻咽癌高发家系、85例散发鼻咽癌患者及 181名正常对照 D6 S15 81位点进行了基因分型、参数 /非参数连锁分析及关联分析。结果　在鼻咽癌家系中 D6 S15 81与鼻咽癌发病连锁 ,L ods值最高为 2 .6 114 36 (P=0 .0 0 2 4 5 ) ,关联分析结果也提示家族性鼻咽癌 D6 S15 81等位基因频率与正常对照组差异有显著性 (P<0 .0 0 5 )。结论　 D6 S15 81与湖南家族性鼻咽癌的发病之间可能有着密切的联系 ,该基因附近可能存在一个或多个与鼻咽癌发生发展有关的基因 ,FBXO30基因很可能就是其中之一。Objective: To investigate the relationship of nasopharyngeal carcinoma (NPC) with the high frequency allele imbalance locus D6S1581, and the NPC associated gene FBXO30 which is located near D6S1581. Methods Genescan was used to genotype D6S1581 of 12 NPC pedigrees, 85 sporadic NPC patients and 181 normal volunteers. Then parametric/nonparametric linkage analysis and association analysis were performed. Results D6S1581 was linked with NPC, a Lod score of 2. 611436 (P = 0. 00245) was obtained, and a significant difference in allele frequency was observed between familial NPC and control (P<0. 005). Conclusion: These results suggest that D6S1581 is highly associated with NPC, and there may be one or more NPC associated genes near D6S1581, including FBXO30.

关 键 词：鼻咽癌 高频等位基因不平衡位点 D6S1581 遗传易感性 基因分型 

分 类 号：R739.63[医药卫生—肿瘤]