贵州汉族群体F13A01、FESFPS、vWA基因座遗传多态性研究  

Genetic polymorphisms of short tandem repeats loci F13A01, FESFPS, vWA from Han population in Guizhou

作　　者：喻芳 周强 何荣跃 吴思鹍 

机构地区：[1]贵州省计划生育科学技术研究所遗传优生中心,贵阳550004

出　　处：《中华医学遗传学杂志》2003年第4期363-364,共2页Chinese Journal of Medical Genetics

摘　　要：目的　了解贵州汉族人群 F13A0 1、FESFPS、v WA的遗传多态性分布 ,获得这 3个多态位点的群体遗传学数据。方法　应用聚合酶链反应复合扩增技术 ,对 16 0名无血缘关系的汉族个体的 F13A0 1、FESFPS、v WA 3个短串联重复序列 (shorttandem repeats,STR)基因座等位基因频率进行了分析。结果3个 STR基因座基因频率的分布均符合 Hardy- Weinberg平衡 ,3个 STR基因座总个体识别率为 0 .9984 ,累积多态信息含量为 0 .97。结论　所得到的等位基因频率数据可为贵州汉族人群法医个体识别、亲子鉴定及遗传学研究提供更多依据。Objective: To understand the allele structure and genetic polymorphism at F13A01, FESFPS and vWA short tandem repeats (STRs) loci for Han population in Guizhou province of China, and to construct a preliminary database. Methods: One hundred sixty unrelated individuals in Han population from Guizhou were analyzed by multiplex polymerase chain reaction. The resultant allele frequencies were compared with those of other population or race database. Results: The genotype distributions of F13A01, FESFPS and vWA were in accordance with Hardy-Weinberg equilibrium. The combined discrimination power and polymorphism information content were 0. 9984 and 0. 97 respectively. Conclusion: All of the three loci in this study provide useful markers for forensic paternity test and for genetic purposes.

关 键 词：贵州 汉族群体 F13A01 FESFPS VWA 基因座 遗传多态性 

分 类 号：R394.1[医药卫生—医学遗传学]