羧乙基锗倍半氧化物(Ge-132)对黄曲霉毒素B1诱导肝癌的化学预防作用  

CHEMOPROPHYLAXIS EFFECT OF CARBOXYETHYLGERMANIUM (GE-132) ON AFB1-INDUCED HEPATO-CARCINOGENESIS

作　　者：黎丹戎[1] 侯华新[2] 涂文升[1] 秦箐[2] 黎远冬[1] 陈艳华[1] 刘宗河[1] 

机构地区：[1]广西肿瘤防治研究所,南宁530021 [2]广西医科大学,南宁530021

出　　处：《中国现代医学杂志》2003年第16期7-9,共3页China Journal of Modern Medicine

基　　金：广西区卫生厅青年基金资助项目 (青 92 0 7)

摘　　要：目的 :应用大鼠短期实验模型进行Ge- 132对黄曲霉毒素B1(AFB1)诱癌的化学预防研究。方法 :实验大鼠按不同处理方法分为 5组 :A组高剂量Ge - 132 ;B组 :低剂量Ge - 132 ;C组 :给AFB1前高剂量Ge -132 ;D组 :给AFB1后高剂量Ge- 132 ;E组 :正常对照。在第九周动物处死后肝组织作低温石蜡连续切片 ,分别染γ -谷氨酰转移酶 (γ -GT) ,血清和肝组织测定其超氧化物歧化酶 (SOD)活性。结果 :Ge - 132具有抵抗AFB1降低SOD活力的作用 ,Ge - 132的摄入时间、剂量可影响大鼠体内SOD活力和γ -GT灶的大小。结论 :实验结果提示Ge - 132的抗氧化作用与抑癌作用有关 ,是一种安全、有效的肝癌化学预防剂。Objective:To determine the protective effect of Carboxyethylgermanium (Ge-132)during AFB1-induced hepato-carcinogenesis for Wistar short term model experiments.Methods:The animals were divided into 5 groups: A: high dosage of Ge-132;B:lower dosage of Ge-132; C: high dosage of Ge-132 before AFB1 exposure; D: high dosage of Ge-132 after AFB1 exposure;E: normal control group.All of the animals were killed at the end of the eight-week experiment .The slides of the liver tissues were stained for γ-Glutamyltransferase (γ-GT) . The activity of SOD in serum and in the liver tissues was measured.Results:Ge-132 possessed the remarkable resistance effects on AFB1 reducing Superoxide Dismutase(SOD) activity in vivo during AFB1-induced hepato-carcinogenesis for short term model experiments. The SOD activity and the size of r-GT can be effected by the time and the dosage of Ge-132 intake.Conclusion:The results indicate that antioxidative ability of Ge-132 is relate to its anticarcinogenicity. Ge-132 can be used as a safe and effective chemoprophylaxis agent.

关 键 词：羧乙基锗倍半氧化物(Ge-132)AFBl 化学预防 超氧化物歧化酶(SOD) 

分 类 号：R735.7[医药卫生—肿瘤]