手性Boc保护氨基酸修饰卟啉的合成及谱学研究  

Synthesis and Spectrum of Chiral Boc Protected Amino Acids Linked Porphyrins

作　　者：赵小菁[1] 阮文娟[1] 张玉玲[1] 韩华[1] 朱志昂[1] 

机构地区：[1]南开大学化学系,天津300071

出　　处：《高等学校化学学报》2003年第8期1419-1423,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 0 1710 2 4) ;天津市自然科学基金 (批准号 :0 2 36 0 40 11);教育部留学回国人员科研基金资助

摘　　要：合成了α,α,α,β-四 -[邻 (叔丁氧羰丙氨酸 )氨基苯基 ]卟啉 H2 T(o-Boc Ala) APP(1 )及其锌 ( )配合物Zn T(o-Boc Ala) APP(Zn-1 ) ,α,α,α,β-四 -[邻 (叔丁氧羰苏氨酸 )氨基苯基 ]卟啉 H2 T(o-Boc Thr) APP(2 )及其锌 ( )配合物 Zn T(o-Boc Thr) APP(Zn-2 ) ,α,α,α,β-四 -[邻 (叔丁氧羰酪氨酸 )氨基苯基 ]卟啉H2 T(o-Boc Tyr) APP(3)及其锌 ( )配合物 Zn T(o-Boc Tyr) APP(Zn-3)等 6种叔丁氧羰保护氨基酸修饰的卟啉 .用元素分析、核磁共振、红外光谱、紫外 -可见光谱以及圆二色谱等手段对其组成的结构进行了表征 ,并对其谱学性质进行了研究 .Meso-tetrakis(o-BocAlamido) porphyrin [H 2T(o-BocAla)APP, 1] and its zinc complex [ZnT(o-BocAla)APP, Zn-1, meso-tetrakis(o-BocThrmido)porphyrin [H 2To-ocAls)APP, and its zinc complex [ZnT(o-BocThr)APP, Zn-2 , meso-tetrakis(o-BocTyrmido) porphyrin [H 2T(o-BocTyr)APP, 3and its zinc complex [ZnT(o-BocTyr)APP, Zn-3] were synthesized and characterized by elemental analyses, FTIR, 1H NMR, UV-Vis and CD. The FTIR spectra and 1H NMR of these complexes were compared and discussed. The UV-Vis and CD spectra of complexes were also attributed and minutely discussed. Compared with ZnTPP, the bands of porphyrins 1, 2, 3 have visibly red-shifts. Obviously, the cotton signals of 1 and 2, 3 are opposite, maybe it was caused by hydroxyl group.

关 键 词：手性Boc保护氨基酸修饰卟啉 合成 叔丁氧羰 圆二色谱 卟啉化合物 锌配合物 核磁共振谱 紫外可见光谱 仿生化学 

分 类 号：O614.241[理学—无机化学] O641.4[理学—化学]