一种南海海绵(Acanthella sp.)的化学成分研究  

STUDIES ON THE CHEMICAL CONSTITUENTS OF MARINE SPONGE ACANTHELLASP.FROM THE SOUTH CHINA SEA

作　　者：严小红[1] 宋国强[1] 周秀红[1] 刘松柏[1] 郭跃伟[1] 

机构地区：[1]中国科学院上海生命科学研究院药物研究所国家新药研究重点实验室,上海200031

出　　处：《天然产物研究与开发》2003年第3期199-202,共4页Natural Product Research and Development

摘　　要：从中国南海海绵 (Acanthellasp .)中分离得到了 11个有机化合物。应用现代波谱技术和X 衍射分析 ,确定其结构分别为 (+) α amuurolene(Ⅰ ) ,(1R ,6S ,7S ,10S) 10 isothiocyanato 4 amorphene(Ⅱ ) ,acantheneB(Ⅲ ) ,isothiocyanate 1(Ⅳ ) ,(+) 10 (R) isothiocyanatoalloaromadendrane(Ⅴ ) ,axisonitrile 3(Ⅵ ) ,kalihinene(Ⅶ ) ,kalihiolA(Ⅷ ) ,胆甾醇 (Ⅸ ) ,麦角甾醇 (Ⅹ )和麦角甾 6 ,2 2 二烯 5 ,8 环二氧 3 醇(Ⅺ )。其中化合物Ⅱ Ⅷ是首次从中国海洋生物中分离得到的异腈萜类化合物。Eleven known compounds were isolated from the marine spongeAcanthellasp.collected from the South China Sea.Their structures were identified,by the means of spectroscopic method andX-raydiffraction analysis,as(+)-α-amuurolene(Ⅰ),(1R,6S,7S,10S)-10-isothiocyanato-4-amorphene(Ⅱ),acanthene B(Ⅲ),isothiocyanate 1(Ⅳ),(+)-10(R)-isothiocyanatoalloaromadendrane(Ⅴ),axisonitrile-3(Ⅵ),kalihinene(Ⅶ),kalihiol A(Ⅷ),cholesterol(Ⅸ),ergosterol(Ⅹ),and ergost-6,22-diene-5α,8α-epidioxy-3β-ol(Ⅺ),respectively.The terpene isonitriles are rare in nature and the compounds Ⅱ-Ⅷ were isolated from the Chinese marine sponges for the first time.

关 键 词：南海海绵 化学成分 异腈萜类化合物 海洋生物 胆甾醇 麦角甾醇 

分 类 号：Q959.12[生物学—动物学] Q5