人骨髓基质细胞上清液对原代白血病细胞的杀伤作用及CFU-F生成的影响  

Effect of Bone Marrow Stromal Cells Supernatant on Primitive Leukemic Cells and CFU-F

作　　者：李兴玉[1] 候相麟[1] 魏虎来[1] 赵怀顺[1] 

机构地区：[1]兰州医学院血液病研究所

出　　处：《兰州医学院学报》1992年第1期33-35,共3页Journal of Lanzhou Medical College

摘　　要：观察了人胎骨髓基质细胞上清液对6例白血病患者骨髓原代白血病细胞存活程度及CFU-F形成的影响。结果表明。骨髓基质细胞上清液对原代白血病细胞具有杀伤作用(p<0.002—0.001)。同时发现基质细胞上清液还能促进CFU-F的形成(p<0.01-0.001)。本文还对上述变化的可能机制进行了讨论。Bone marrow primitive leukemic cells from 6 patients withacute leukemia were treated with fetal bone marrow stromal cells supernatant for a week ,and than, to detect living cells in liquid culture and CFU-F. The living cells in liquid culture significantly reduced (P<0.002-0.001) and CFU-F of 5/6 patients were significantly induced (P<0.01-0.001) as compared with the control. There was close negative correlation between the living cells and the concentration of bone marrow stromal cells supernatant (r =-0.71,P<0.01). The results showed that the fetal bone marrow stromal cells supernatant could kill primitive leukemic cells and promote CFU-F growth.

关 键 词：骨髓基质细胞 白血病 抗肿瘤效应 

分 类 号：R733.705[医药卫生—肿瘤]