三维立体定向放射治疗肺癌  

Stereotactic radiotherapy for lung carcinoma

作　　者：侯宁农[1] 赵卫生[1] 

机构地区：[1]天津环湖医院外科,天津300060

出　　处：《中国微创外科杂志》2003年第4期313-314,共2页Chinese Journal of Minimally Invasive Surgery

摘　　要：目的　探讨立体定向放射治疗肺癌的临床疗效。　方法　 2 7例肺癌采用CT定位 2mm层厚连续扫描并通过图像重建 ,计算出临床靶体积 (CTV) ,计划靶体积 (PTV)及受累器官体积的照射量 -体积直方图。应用德国Leibinger的立体定向系统和Varian 6 0 0c加速器进行治疗。采用中等剂量 ,每次 5Gy～ 7Gy ,每日一次 ,连续治疗 5次～ 8次。　结果　本组 2 7例肺癌在接受立体定向放射治疗过程中无死亡 ,患者一般状况评分采用Karnofsky(KPS)标准。术前KPS评分 2 0～ 80分 ,平均 5 9分。术后KPS评分 2 0～ 10 0分 ,平均 87分。随访 2月～ 5 8月 ,平均 2 6月 ,按实体瘤疗效标准 :完全缓解 (CR) :4例 ;部分缓解(PR) :17例 ;无变化 (NC) :2例 ;进展 (PD) :4例。肿瘤控制有效率 85 % (2 3 2 7)。　结论　立体定向放射治疗肺癌近期疗效良好。Objective To discuss the clinical effects of stereotactic radiotherapy in the management of lung cancer. Methods Included in this study there were 27 patients with lung cancer. After the lesions were localized by CT scans with 2 mm slice thickness, the images were reconstructed and clinical tumor volume (CTV), planning tumor volume (PTV) and dose-volume histograms of the involved lung were calculated. By using Leibinger stereotactic radiotherapy planning system and Varian Clinic 600C, a series of 5～8 fractions of radiotherapy were carried out once daily with 5～7 Gy per fraction. Results None of the 27 patients died during the treatment. General conditions of the patients were assessed by means of Karnofsky performance status (KPS). Preoperative KPS scores were 20～80 (mean 59), while postoperative KPS scores were 20～100 (mean 87). Follow-up information revealed 4 cases of complete remission, 17 cases of patial remission, 2 cases of no change and 4 progressed, with control rate being 85%. Conclusions Stereotactic radiotherapy provides excellent short-term curative effects in the treatment of lung carcinoma.

关 键 词：肺癌 立体定向放射治疗 

分 类 号：R734.2[医药卫生—肿瘤]