调补气血针法对SAMP10脑中枢神经递质含量影响的研究  

Study on Tiao Bu Qi Xue Acupuncture Acting on the Changes of Central Neurotransmitter in the Brain

作　　者：王彤[1] 庞莹[1] 丁晓蓉[1] 于涛[1] 刘庆忠[1] 王舒[1] 韩景献[1] 

机构地区：[1]天津中医学院第一附属医院老年病研究室,天津300193

出　　处：《辽宁中医杂志》2003年第8期663-664,共2页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的 :旨在揭示调补气血针法治疗痴呆的中枢作用机制。方法 :采用HPLC -ECD法对SAMP10及SAMR1脑组织单胺类神经递质和乙酰胆碱 (Ach)含量进行测定。结果 :①SAMP10脑组织DA、5 -HT、Ach的含量显著低于SAMR1的含量 ;②调补气血针法可使脑组织降低的DA、5 -HT、Ach的含量显著提高。结论 :①SAMP10小鼠的学习、记忆障碍发病机制之一可能是脑组织Ach和单胺类神经递质的代谢异常出现了神经损害 ;②调补气血针法改善了SAMP10的学习。Objective :to explore the effects of Tiao Bu Qi Xue acupuncture principle on the changes of central neurotransmitter in the brain. Method :The amount of Monoamine neurotransmitter and Ach in SAMP10 and SAMR1 brain is observed by high-performance liquid chromatograph with electrochemical detector method (HPLC-ECD). Results :①The amount of DA,5-HT and Ach in SAMP10 brain is greatly lower than those of SAMR1.②The amount of DA,5-HT and Ach in Tiao Bu Qi Xue group increased more significantly than those in the SAMP10 group. Conclusion :①The abnormal metabolism of Monoamine neurotransmitter and Ach in brain is one mechanism of SAMP10 to learn and memorize declining.②Tiao Bu Qi Xue acupuncture principle improved ability of SAMP10 to learn and memorize.

关 键 词：自然快速老化脑萎缩及痴呆模型小白鼠(SAMP10) 调补气血针法 中枢神经递质 实验研究 

分 类 号：R0-33[医药卫生]