在18—冠—6硅胶键合固定相上有机酸及其异构体的高效液相色谱研究  

HPLC Study of Aromatic Acids and Some Isomers on 18-crown-6 Silica-bonded Stationary Phase

作　　者：刘武平[1] 达世禄 

机构地区：[1]武汉大学化学系,武汉430072

出　　处：《离子交换与吸附》1992年第6期513-517,共5页Ion Exchange and Adsorption

基　　金：国家自然科学基金

摘　　要：本文报导了一种新型18—冠—6硅胶键合固定相(P18—C—6SB)在有机酸分析中的应用。流动相组成为Cu^(2+)离子、甲醇和HAC—NaAc缓冲溶液。研究了流动相中甲醇体积比、Cu^(2+)离子浓度、缓冲溶液浓度及pH值等因素对容量因子(K’)的影响。在优化条件下,成功地分离了包括氨基取代苯甲酸异构体在内的多种芳香酸。This paper reports the chromatographic separation of aromatic acids and some isomers on a new stationary phase named 18-crown-6 modified silica (P18-c-6SB). The mixture of Cu(Ⅱ)-methanol-acetate buffer was used as mobile phase,and the effects of each part and the pH value in mobile phase on K' have been studied in detail. Under the optimum conditions, aromatic acids including some isomers can be separated successfully.

关 键 词：有机酸 高效液相色谱 固定相 

分 类 号：O622.5[理学—有机化学]