不能手术切除的非小细胞肺癌集束电极射频治疗的初步探讨  

RF Ablation of unresectable non-small cell lung cancer

作　　者：王远东[1] 赵健[1] 林本理[1] 刘健雄[1] 邵中夫[1] 陈贵全[1] 李洪胜[1] 

机构地区：[1]广州医学院临床肿瘤中心暨广州市肿瘤医院,广州510095

出　　处：《临床肿瘤学杂志》2003年第4期244-247,共4页Chinese Clinical Oncology

摘　　要：目的 :探讨应用集束电极射频 (radiofrequencyablation ;RFA)治疗不能手术切除的非小细胞肺癌的可行性和近期疗效。方法 :在CT引导下经皮肺穿刺或术中直视下RFA治疗不能手术切除的非小细胞肺癌 ,随访观察治疗近期效果、中位生存期、1年生存率、2年生存率及围手术期并发症。结果 :86例患者共 92个肿瘤病灶用RFA治疗 ,术后并发气胸 16例 ,随访5～ 36个月。治疗后 1个月 41 86 %的KPS评分改善。 16例出现局部复发 ,其中 9例患者再次RFA。中位生存时间为 14个月 ,1年生存率为 78 15 %,2年生存率为 46 88%。结论 :RFA治疗不能手术的非小细胞肺癌创伤小 ,可重复治疗 ,安全可靠 ,局部治疗效果较好。Objective:The aim of this study was to evaluate feasibility and effectiveness of radiofrequency ablation, performed by using a clustered electrode needle, in the treatment of unresectable non-small cell lung cancer.Methods:The lung tumors were treated percutaneously under CT scan guidance or during surgery using a EVB electrode needle and an RF 2 000 generator. All patients are followed to assess treatment response, median survival times, one year survival rate, two year survival rate and perioperative complication.Results:RFA was used to treat 92 tumors in 86 patients. Major postoperative complication was pneumothorax occurred in 16 patients. During 5～36 months follow-up period, the rate of improvement of KPS for patients in the synthetic group was 41.86%. Tumor has recurred in 16 patients. RFA was repeated in 9 patients of recurrence. Median survival times was 14 months. One year survival rate was 78.15%, two year survival rate was 46.88%.Conclusion:RF ablation by EVB electrode needle is a minimally invasive, safe and effective technique for unresectable non-small cell lung cancer.

关 键 词：不能手术切除 非小细胞肺癌 集束电极射频治疗 围手术期 并发症 随访 

分 类 号：R734.2[医药卫生—肿瘤] R730.5[医药卫生—临床医学]