脑健冲剂对AD模型大鼠行为学及线粒体结构影响的实验研究  

EXPERIMENTAL STUDY ON THE EFFECT OF NAOJIAN MEDICINE ON THE BEHAVIORAL AND MORPHOLOGIC STUDY OF SIMULATED AD RATS

作　　者：刘长发 杨春壮[2] 杨春佳 

机构地区：[1]哈尔滨市盲聋哑学校,150008 [2]牡丹江医学院 [3]佳木斯铁路中心医院

出　　处：《牡丹江医学院学报》2003年第4期6-8,共3页Journal of Mudanjiang Medical University

摘　　要：目的 :研究脑健冲剂对AD模型大鼠行为学及线粒体超微结构的影响。方法 :采用D -半乳糖致衰老与 β -淀粉样蛋白注射联合所致的AD大鼠模型 ,服用脑健冲剂 ,测试大鼠在迷宫中的学习及记忆能力和海马CA1区线粒体体密度、面数密度等形态学指标。结果 :脑健冲剂能有效的改善AD模型大鼠的学习、记忆障碍 ,并能很好地改善线粒体结构的受损程度。结论 :脑健冲剂对AD有较明显的治疗作用 ,为临床应用脑健冲剂治疗AD提供实验依据。Objective: To study the effect of Naojian medicine on the behavioral and mitochondrial study of simulated AD rats. Methods: made simulated AD model rats by integrated D-semilactose emergency aged and β-amyloid protein injection, after taking Naojian medicine, test the study and rememorial ability of rats in labyrinth,the density of mitochondrial volume and the number of surface in CA1 of hippocampi of simulated AD rats. Results: Naojian medicine can effectively improve study, memory obstacle and lighten damage of mitochondrial of simulative AD rats. Conclusion: Naojian medicine has an obvious treatment of AD, thus provide an objective estimation for clinical application.

关 键 词：脑健冲剂 AD 动物模型 大鼠 行为学 线粒体结构 实验 

分 类 号：R277.791.6[医药卫生—中医学] R285.5