胶带粘贴试验前后皮肤生物物理参数的变化  

Changing of Biophysical Parameter of Skin Before and After Tape-stripping Test

作　　者：吴琰瑜[1] 王学民[2] 周玉田[2] 谈益妹[2] 程英[2] 叶蔓莉[2] 储蕙[2] 林银芬[2] 张清祥[2] 陈德利[1] 

机构地区：[1]上海同济大学医学院,上海200065 [2]上海市皮肤病性病医院

出　　处：《中国中西医结合皮肤性病学杂志》2003年第1期29-32,共4页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的了解6个皮肤生物物理参数在皮肤受到物理性刺激后变化情况。方法用3M胶带粘贴面部2次,臂部10次,在粘贴前及粘贴至2、5、10次时进行经表皮失水率(transepidermalwaterloss,TEWL)、皮肤电容量(capicitance,CAP)、红斑指数(erythema-index,EX)、黑素指数(melanin-index,MX)、L、a的检测。结果发现面部粘贴后TEWL、CAP、EX、L、a均增高,而MX降低;臂部随粘贴次数的增加,TEWL、CAP及L增高,MX降低,EX及a先减小,后增大。粘贴至2、5、10次时各检测值及基础值间两两比较,TEWL差异均有显著性(P<0.05)。结论提示6个皮肤生物物理参数可以反映皮肤受到物理性刺激后的变化,以TEWL较为敏感。Objective To understand the changing of6noninvasive biophysical parameters of skin after physical ir-ritant,such as tape-stripping.Methods Face was stripped for2times and flexure of forearm was stripped for10times.Transepidermal water loss(TEWL ),capicitance(CAP),erythema-index(EX),melanin-index(MX),Land awere measured before stripping and at2,5,10times of stripping.Results TEWL,CAP,EX,Land aincreased and MX de-creased after stripping on face.On forearm,tendency of increase in TEWL and CAP,that of decrease in MX,first increase then decrease in EX and a,were observed according to the times of stripping.Compared baseline and parameters of stripping2,5and10times with each other,TEWL is different significantly only(P<0.05).Conclusion The6noninva-sive biophysical parameters adapt to assess intensity of changing of skin after physical irritant.Among them TEWL is the most sensitive one.

关 键 词：胶带粘贴试验 皮肤生物物理参数 经表皮失水率 电容量 颜色测量法 皮肤屏障功能 

分 类 号：R334.5[医药卫生—人体生理学]