Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats  

作　　者：Jin-LianChen TongZhou Wei-XiongChen Jin-ShuiZhu Ni-WeiChen Ming-JunZhang Yun-LinWu 

机构地区：[1]DepartmentofGastroenterology,ShanghaiSixthPeople'sHospital,ShanghaiJiao-TongUniversity,Shanghai200233,China [2]TongZhou,DepartmentofNephrology,RuijinHospital,ShanghaiSecondMedicalUniversity,Shanghai200025,China [3]AnimalLaboratory,RuijinHospital,ShanghaiSecondMedicalUniversity,Shan~,hai200025,China [4]DepartmentofGastroenterology,RuijinHospital,ShanghaiSecondMedicalUniversity,Shanghai200025,China

出　　处：《World Journal of Gastroenterology》2003年第7期1563-1566,共4页世界胃肠病学杂志（英文版）

基　　金：the National Natural Science Foundation of China(No.39970340);the Scientific Foundation of Ministry of Public Health

摘　　要：AIM: To investigate the effect of tetramethylpyrazine on hepatic/renal ischemia and reperfusion injury in rats. METHODS: Hepatic/renal funclJon, histopathotogical changes, and hepatic/renal P-selectin expression were studied with biochemical measurement and immunohistochemistry in hepatic/renal ischemia and reperfusion injury in rat models. RESULTS: Hepatic/renal insufficiency and histopathological damage were much less in the tetramethylpyrazine-treated group than those in the saline-treated groups. Hepatic/renal P-selectin expression was down regulated in the tetramethylpyrazine-treated group. CONCLUSION: P-selectin might mediate neutrophil infiltration and contribute to hepatic/renal ischemia and reperfusion injury. Tetramethylpyrazine might prevent hepatic/renal damage induced by ischemia and reperfusion iniury throuclh inhibition of P-selectin.AIM:To investigate the effect of tetramethylpyrazine on hepatic/renal ischemia and reperfusion injury in rats. METHODS:Hepatic/renal function,histopathological changes, and hepatic/renal P-selectin expression were studied with biochemical measurement and immunohistochemistry in hepatic/renal ischemia and reperfusion injury in rat models. RESULTS:Hepatic/renal insufficiency and histopathological damage were much less in the tetramethylpyrazine-treated group than those in the saline-treated groups.Hepatic/ renal P-selectin expression was down regulated in the tetramethylpyrazine-treated group. CONCLUSION:P-selectin might mediate neutrophil infiltration and contribute to hepatic/renal ischemia and reperfusion injury.Tetramethylpyrazine might prevent hepatic/renal damage induced by ischemia and reperfusion injury through inhibition of P-selectin.

关 键 词：川芎嗪 P-选择素 肝 肾 缺血再灌注损伤 中性粒细胞 

分 类 号：R575[医药卫生—消化系统] R692[医药卫生—内科学]