联合用药治疗强迫症的双盲对照研究  

Double-blind Control Research of Treating the Obsessive-compulsive Disorder by Combined Medicine

作　　者：刘薇[1] 吴铮[1] 韩海英[1] 王庆志[1] 陶永红[1] 胡建[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院精神科,黑龙江哈尔滨150050

出　　处：《黑龙江医学》2003年第8期568-570,共3页Heilongjiang Medical Journal

基　　金：黑龙江省卫生厅科研 (2 0 0 2 - 0 2 9)

摘　　要：目的　采用联合用药方法 ,探索治疗强迫症的新方法。方法　将符合入组条件的 6 0例强迫症患者随机分成 2组 ,联合用药组采用氯丙咪嗪、舍曲林和苯妥英钠同时治疗 ,对照组用氯丙咪嗪治疗 ,用药 8周 ,通过Y -Bocs量表和疗效量表 (CGI)观察疗效。结果　联合用药组在治疗 8周时Y -Bocs减分率为71 8% ,氯丙咪嗪组为 5 2 8% ,2组评分差异有显著性 (P <0 0 5 ) ,且不良反应无显著差异。结论　联合用药治疗强迫症效果明显 。Objective To find out the way of treating obsessive-compulsive disorder (OCD) by combined medicine. Methods 60 patient who obtained the diagnostic criteria were divided into treatment group and control group. The treatment group was given chlorimipramine, sertraline and phenytoin sodium together at the same time and patients of the control group only used the chlorimipramine. Two groups had been treated for 8 weeks and the effects of therapy were observed by using Y-Bocs and treatment effect scale . Results At the 8th week, the Y-Bocs subtractive score rate of the combined medicine group was 71.8% and that of the chlorimipramine group was 52.8%. The difference between two groups was significant (P<0.05) and there was no significant difference in the side effects between two groups. Conclusion There might be a prominent effect in treating the OCD by combined medicine which would be good to cure this kind of disease.

关 键 词：精神病学 联合用药 强迫症 双盲对照研究 氯丙咪嗪 舍曲林 苯妥英钠 

分 类 号：R749.99[医药卫生—神经病学与精神病学] R969.4[医药卫生—临床医学]