小分子肝素,三氧化二砷治疗急性早幼粒细胞白血病合并弥散性血管内凝血初步观察  

EFFECTIVENESS OF LOW MOLECULAR WEIGHT HEPARIN COMBINED WITH ARSENIC TRIOXIDE IN TREATMENT OF ACUTE PROM,YELOCYTIC LEUKEMIA WITH DISSMINATED INTRAVASCULAR COAGULATION

作　　者：吴楠[1] 杨惠芬[2] 胡龙虎[2] 周晋[2] 

机构地区：[1]广东省广州市第十二人民医院,510620 [2]哈尔滨医科大学第一临床医学院,150001

出　　处：《中国现代医学杂志》2003年第13期59-60,共2页China Journal of Modern Medicine

摘　　要：目的 :应用小分子肝素 (LMWH)、三氧化二砷 (As2 O3 )治疗急性早幼粒细胞白血病 (APL)合并弥散性血管内凝血 (DIC)疗效的观察 ,方法 :APL诊断确定即开始皮下注射LMWH和静滴AS2 O3 ,D -二聚体阴性时则停用LMWH。结果 :初治和复发病例中亚急性和慢性DIC疗效较好 ,初治病例中急性DIC疗效差。总治愈率为 90 % ,副反应轻。结论 :LMWH利As2 O3 联合应用治疗APL合并DIC的治愈率高 ,LMWH和As2 O3 是目前治疗APL合并DIC较理想的药物。Objective:To observe the effectiveness of low molecular weight heparin (LMWH) in combination with arsenic trioxide (AS 2O 3) in treatment of acute promye locytic leukemia(APL) with disseminated intravascular coagulation (DIC) .Methods:After diagnosis,LMWH and AS2O3 were administrated to forty patients,LMWH was withdrawed when D-direct in patients blood as an evaluation key was negative.Results:The effectiveness is better in both previously untreated and relapsed cases with subacute and chronic DIC, comparing with that in the previously untreated cases suffered acute DIC. In general, the effec tiveness in this observation is 90%.Conclusions:The effectiveness of LMWHand A8203 in APL with DIC was better than those of previously therapies.

关 键 词：三氧化二砷 小分子肝素 急性早幼粒细胞白血病 

分 类 号：R733.71[医药卫生—肿瘤]