粘附分子在复发性口腔溃疡的发病机制中作用的探讨  

Expression of vascular cell adhesion molecule-1 in recurrent oral ulceration

作　　者：孙睿[1] 董玙[1] 晁海英[1] 孙晓震 

机构地区：[1]兰州医学院第二附属医院口腔科,730030 [2]太原山西省中医药研究所骨科

出　　处：《实用口腔医学杂志》2003年第4期301-303,共3页Journal of Practical Stomatology

摘　　要：目的 :探讨可溶性血管内皮细胞粘附分子 (sVCAM 1)、可溶性细胞间粘附分子 (sICAM 1)在复发性口腔溃疡 (recurrentoralulceration ,ROU)发病机制中的作用。方法 :采用双抗体夹心酶联免疫吸附实验法检测血清中的sVCAM 1、sICAM 1浓度。结果 :ROU患者的sVCAM 1浓度高于健康对照组 ,差异有显著性。ROU患者的sICAM 1浓度与健康对照组相比无显著性差异。sVCAM 1、sICAM 1两者浓度在活动期与静止期差异无显著性。结论 :sVCAMObjective: To study the effects of soluble vascular endothelial cell adhesion molecule-1(sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) in recurrent oral ulceration (ROU). Methods: sVCAM-1 and sICAM-1 in oral menbrane tissue sampls were measured with an enzyme linked immunosorbent assay using sandwich technices in 45 patients with ROU and 40 nomal controls. Results: The expression level of sVCAM-1 in the oral membrane tissue samples of ROU patients was higher than that in the controls (P<0.05). sICAM-1 expression in patients were similar to that in the control(P>0.05). Both sVCAM-1 and sICAM-1 expression were not significantly different with the stages (ROU-active and ROU-free) of the lesion. Conclusion: sVCAM-1 might play a role in ROU.

关 键 词：复发性口腔溃疡 发病机制 粘附分子 可溶性血管内皮细胞粘附分子 可溶性细胞间粘附分子 

分 类 号：R781.5[医药卫生—口腔医学]