肱动脉血流介导的血管舒张评价氯沙坦对高血压患者血管内皮功能的影响  

The effect of losartan on endothelial function in patients with essential hypertension by measuring flow-mediated vasodilation

作　　者：李丽[1] 盛铁仁[1] 马玉山[1] 苏双善[1] 沙林彪[1] 

机构地区：[1]甘肃省人民医院心内科,730000

出　　处：《国外医学（心血管疾病分册）》2003年第4期245-247,共3页

摘　　要：目的:采用肱动脉血流介导的血管扩张(FMD)评价氯沙坦对高血压患者血管内皮功能的影响。方法:测定20例轻、中度原发性高血压患者肱动脉基础FMD及最大血流速度(Vmax)。予以口服氯沙坦50mg/d,8周后复查FMD及Vmax,同时观测血压变化。结果:口服氯沙坦8周后肱动脉血管内径无明显变化,而FMD由(4.64±3.72)％增大到(7.68±16.12)％,加压前Vmax、加压后Vmax较服药前增大,有统计学意义(P<0.05),且FMD的增大与血压降低并无相关性。结论:肱动脉FMD可以作为评价内皮依赖性血管扩张的有效方法;口服氯沙坦8周可以改善高血压患者血管内皮依赖性舒张功能,且这种改善与血压降低不相关。Objective: To investigate the effect of losartan on endothelial function in patients with essential hypertension by using flow-mediated vasodilation(FMD) of brachial artery. Methods: We tested the basic FMD and maximum velocity(Vmax) of brachial artery in 20 patients with essential hypertension. After giving the patients 50mg losartan per day for 8 weeks, the FMD and Vmax was tested again. The blood pressure (BP) was measured simultaneously. Results: After the treatment there were no significant changes of brachial artery initial diameter while FMD increased significantly (4. 64% ± 3. 72% vs 7. 68% ± 6. 12% , P = 0.024) and the change was independent of BP decreasing. The Vmax was also increased significantly. Conclusions: The brachial FMD can be regarded as a useful method to evaluate endothelial-dependent vasodilative function. Flow-mediated brachial artery dilation would be improved afer taking losartan 50mg/d for 8 weeks, and this is independent of BP decreasing.

关 键 词：高血压 氯沙坦 肱动脉血流 血管扩张 血管内皮功能 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]