酒精性肝病患者血浆内毒素水平检测及临床意义  

MEASUREMENT OF PLASMA ENDOTOXIN LEVEL IN PATIENTS WITH ALCOHOLIC LIVER DISEASES

作　　者：王超[1] 臧丽华[1] 高志红[1] 

机构地区：[1]大连医科大学附属第一医院消化科,辽宁大连116011

出　　处：《医师进修杂志》2003年第8期13-14,共2页Journal of Postgraduates of Medicine

摘　　要：目的　检测不同阶段酒精性肝病患者的外周血内毒素水平 ,探讨此类肝病患者内毒素血症的发病情况 ,以指导治疗。方法　选择酒精性脂肪肝、酒精性肝炎、酒精性肝硬化患者与正常对照组 ,4组共 98例。测外周血浆内毒素定量。结果　酒精性脂肪肝、酒精性肝炎、酒精性肝硬化内毒素血症的发病率分别为 1 2 1 2 %、55 55 %及68 0 1 % ,高于正常对照组 (9 0 0 % ) ,酒精性肝炎、酒精性肝硬化与正常对照组比较差异显著 (P <0 .0 1 )。酒精性脂肪肝、酒精性肝炎、酒精性肝硬化血浆内毒素含量较正常对照组相比升高 ,后二者同正常对照组比较差异显著 (P <0 .0 1 )。结论　酒精性肝病患者内毒素血症发病率增高 ,纠正内毒素血症治疗 。Objective\ to measure plasma endotoxin in patients with alcoholic liver diseases.Methods\ The peripheral blood plasma endotoxin level were quantitatively measured in the following four groups of subjects (98 cases), including alcoholic fatty liver,alcoholic hepatitis,alcoholic liver cirrhosis and normal controls by Matrix Chromo-Hao test .Results\ Endotoxin was detected in 9.00% in the normal controls and in 12.12% of patients with alcoholic fatty liver,55.55% in alcoholic hepatitis and 68.01% in alcoholic liver cirrhosis .Except patients with alcoholic fatty liver, the endotoxin levels in the others were significantly higher than normal controls (P<0.01).And the peripheral blood plasma endotoxin levels in the latter two groups was also significantly higher than the nomal controls (P<0.01).Conclusion\ There is a higher incidence of endotoxemia in patients with alcoholic liver diseases.

关 键 词：酒精性肝病 内毒素血症 发病率 含量 

分 类 号：R575[医药卫生—消化系统]