Src蛋白研究进展  

Progress in Src protein

作　　者：谢捷[1] 龚兴国[1] 曾冬云[1] 

机构地区：[1]浙江大学生命科学学院,浙江杭州310027

出　　处：《中国病理生理杂志》2003年第8期1119-1124,共6页Chinese Journal of Pathophysiology

基　　金：浙江省自然科学基金项目 (No.396 0 0 7) ;浙江大学曹光彪科技基金项目 (No .1710 2 6 )

摘　　要：Src is a non-receptor protein tyrosine kinase activated by a number of extracellular signal moleculars. It is recruited to peripheral sites through myristoylation and the SH3 domain. Src initiates intracellular signal trandsduction pathways that influence cell adhesion, migration, growth, differentiation and survival though catalytic domain. Src is normally maintained in an inactive conformation because of carboxy terminal Src kinase, but can be activated transiently during cellular events such as mitosis or constitutively by abnormal events such as mutation and some cancers. In additions, c-Src protein is found to be highly activated and the Src gene is frequently over-expressed in many cancers. These findings suggest that the relationship between c-Src activation/over-expression and cancer progression appears to be significant.Src is a non-receptor protein tyrosine kinase activated by a number of extracellular signal moleculars. It is recruited to peripheral sites through myristoylation and the SH3 domain. Src initiates intracellular signal trandsduction pathways that influence cell adhesion, migration, growth, differentiation and survival though catalytic domain. Src is normally maintained in an inactive conformation because of carboxy terminal Src kinase, but can be activated transiently during cellular events such as mitosis or constitutively by abnormal events such as mutation and some cancers. In additions, c-Src protein is found to be highly activated and the Src gene is frequently over-expressed in many cancers. These findings suggest that the relationship between c-Src activation/over-expression and cancer progression appears to be significant.

关 键 词：癌基因蛋白质c—src 粘着斑激酶 细胞运动 细胞存活 信号转导 肿瘤 

分 类 号：R363[医药卫生—病理学]