采用组织芯片技术研究乳腺癌中p27和cyclinE的表达  

By using tissue chip technique to study the expression of p27 and cyclinE in breast carcinoma

作　　者：戴艳枝[1] 刘勇[1] 袁晟[1] 邓宇[1] 

机构地区：[1]江西省人民医院,南昌330006

出　　处：《江西医药》2003年第4期252-254,共3页Jiangxi Medical Journal

摘　　要：Objective To study the expressions of p27,cyclinE and analysis it s meaning in breast carcinoma.Methods By using tissue chip tech-nique creating80c ases breast carcinoma tissue chip.at the same time using the S-P immunohis-to chemical methods,the expressions of p27and cy-clinE in breast carcinoma tissue chip was studied.Results The positive rates of p27and cyclinE were38.8%and52.5%i n80cases breast carcino-ma respectively.A significant correlation was found be tween the lowexpression of p27,overexpression of cyclinE and metastasis of lymph node in breast carcinoma.A significant correlation was found be-tween the lowe xpression of p27and overexpression of cyclinE in breast carcinoma.Conclusion The expression of p27and cyclinE might be considered to be a reference indicator f or prognosis of breast carcinoma.The lowexpression of p27has an ability to effec t the overexpression of cyclinE in breast carcinoma.It is feasible to utilize ti ssue chip for a rapid,economic and accurate screening of clinical tissue specime ns on a large scale.Objective To study the expressions of p27,cyclinE and analysis it s meaning in breast carcinoma.Methods By using tissue chip tech-nique creating80c ases breast carcinoma tissue chip.at the same time using the S-P immunohis-to chemical methods,the expressions of p27and cy-clinE in breast carcinoma tissue chip was studied.Results The positive rates of p27and cyclinE were38.8%and52.5%i n80cases breast carcino-ma respectively.A significant correlation was found be tween the lowexpression of p27,overexpression of cyclinE and metastasis of lymph node in breast carcinoma.A significant correlation was found be-tween the lowe xpression of p27and overexpression of cyclinE in breast carcinoma.Conclusion The expression of p27and cyclinE might be considered to be a reference indicator f or prognosis of breast carcinoma.The lowexpression of p27has an ability to effec t the overexpression of cyclinE in breast carcinoma.It is feasible to utilize ti ssue chip for a rapid,economic and accurate screening of clinical tissue specime ns on a large scale.

关 键 词：组织芯片技术 研究 乳腺癌 P27 CYCLINE 表达 

分 类 号：R737.9[医药卫生—肿瘤]