造血系统恶性疾病患者尿喋呤物质含量的测定及其临床意义  

Urinary Pterins Determination and Clinical Significapce in Patients with Malignant Disease of Hemopoietic System

作　　者：韩云峰[1] 陈学民[1] 乔慧[1] 洪顺儿[1] 王无忌[2] 

机构地区：[1]西安医科大学第一附属医院血液内科 [2]陕西省人民医院血液病研究室

出　　处：《临床血液学杂志》1992年第1期19-21,共3页Journal of Clinical Hematology

摘　　要：本文用荧光分光光度计测定了84名正常健康人及32例造血系统恶性疾病患者尿喋呤物质含量,发现正常健康人尿喋呤物质排出量无性别及年龄差异,而造血系统或累及造血系统的恶性疾病患者尿喋呤类物质排出量明显增加。对部分白血病病人化疗前后尿喋呤物质含量的测定,发现其排出量与白血病细胞负荷数呈一致性变化。所以,用本法可作为一种监测白血病化疗效果的辅助指征。The level of urinary pterins of 84 healthy human subjectsand 32 patients with malignant diseases of hemopoietic system were me-asured with fluorospectrophotometric method. The amount of urinary pte-rins in healthy human subjects is insignificant in different sex or agegroups. but that of the patients with leukemia, multiple myeloma andlymphoma were significantly higher levels. According to the observationin our research we suggest that the excreted levels could reflect the inc-rease and decrease of leukemia cells in patients with leukemia. So thismethod can be employed as on index for monitoring the effect of chemo-therapy on leukemia.

关 键 词：尿喋呤 白血病 造血系肿瘤 

分 类 号：R733[医药卫生—肿瘤]