流式细胞术对子宫内膜疾患的评价  

An Valuation of Flow Cytometric Technique For 4 Kinds oF Endometric Diseases

作　　者：范嫏娣 王开伟 许锡禹 刘桂馨[2] 陈有仲[2] 左连富[3] 

机构地区：[1]天津第三中心医院,300120 [2]天津中心妇产医院 [3]河北省肿瘤医院

出　　处：《临床与实验病理学杂志》1992年第1期9-12,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：收集子宫内膜疾患27例,第一组为子宫内膜囊性增殖5例,第二组为子宫内膜不典型增殖5例,第三、四组分别为子宫内膜腺癌2例及子宫内膜间质肉瘤5例。以流式细胞术测定上述四种疾患DNA指数、细胞周期分布及细胞分裂增殖指数。经统计学处理,证实DNA指数第一组与第二、三、四组相比P值<0.05、0.01、0.01。细胞周期分布中,S期百分率:第一组与第四组相比,P值<0.01。结果表明子宫内膜各组疾患的DNA指数比S期百分率更有显著差异,有助于对临界病变进展的预测及预后的估价。The 27 cases of endometric diseases(include 5 cases of eadometrium hyperplasia in group Ⅰ, 5 cases of atypical hyperplasia endometrium in group Ⅱ, 12 cases of endometric adenocarcinoma in group Ⅲ, and 5 cases of endometric stromal sarcoma in group Ⅳ.) were studied retro-spectively by flow eytometric technique for DNA index, the phases of cell cycle and proliferation index. By statistical treatment, it was shown that the DNA index of group Ⅰ was significantly different from that of group Ⅱ, Ⅲ and Ⅳ( P<0.05, 0.01 and 0.01) respectively. The S-phase fraction of the cell cycle of group Ⅰ was significantly from that of group Ⅳ(P<0.01). The results indicate that the DNA index is more sensitive than S-phase fraction for valuation of above-mentioned. Therefore, the DNA index was more helpful to the predication and prognosis in the advances of the borderline diseases.

关 键 词：流式细胞术 囊性增殖 子宫内膜 

分 类 号：R737.33[医药卫生—肿瘤]