乳腺癌及癌前病变细胞DNA的定量分析及其与激素受体、癌胚抗原的关系  

Evaluation of DNA Content in Precancerous and Cancerous Mammary Lesions and Its Relationship to Steroid Hormone Receptors(SR) and CEA

作　　者：王保太[1] 吴强[1] 杨枫[1] 饶慧蓉[2] 郑国豪[2] 胡关林[3] 黄晓赤[4] 

机构地区：[1]安徽医科大学病理学教研室,合肥230032 [2]安徽医科大学附一院病理科,合肥230022 [3]安徽医科大学卫生统计教研室,合肥230032 [4]成都市第六人民医院病理科,四川630051

出　　处：《临床与实验病理学杂志》1992年第2期90-94,共5页Chinese Journal of Clinical and Experimental Pathology

摘　　要：检测119例乳腺癌及40例癌旁增生性病变的DNA含量、类固醇激素受体(SR)和癌胚抗原(CEA)表达。结果显示:正常导管上皮、不同级别的癌旁增生上皮和癌细胞的DNA含量均有明显差异。多倍体的出现是细胞恶变的早期表现。癌细胞DNA含量与SR水平呈负相关,而与CEA表达呈正相关。SR阳性乳癌患者术后存活5年以上者DNA含量和核面积均小于5年内死亡者。DNA content, CEA and SR including receptors of estrogen (ER), progesterone (PR) and androgen(AR) were studied in 119 cases of breast carcinoma and 40 cases of atypical and simple hyperplasia of perieancerous epithelia and normal duct cells of mammary. The results showed that DNA levels in normal duct cells, different grades of hyperplasia and cancer cells were significantly different. The appearance of aneuploidy implied early change to malignancy. There was also found that tumors with negative SR or positive CEA had lower DNA levels. The mean values of DNA content and nuclear area of positive SR tumors were lower in patients survived more than 5 years than those survived less in 5 years.

关 键 词：乳腺癌 癌前病变 DNA 癌胚抗原 

分 类 号：R737.9[医药卫生—肿瘤]