乳腺癌转铁蛋白受体的临床病理观察  

Clinical Pathological Observation of Transferrin Receptor Expression in Human Breast Cancer

作　　者：宋胜华[1] 吴强[1] 杨枫[1] 龚西瑜[2] 郑国豪[2] 孙孟红[3] 

机构地区：[1]安徽医科大学病理学教研室 [2]安徽医科大学附院病理科,合肥230022 [3]南开大学医学院病理学教研室,天津300071

出　　处：《临床与实验病理学杂志》1992年第2期110-112,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：应用抗转铁蛋白受体(TrfR)单克隆抗体(OKT_9)对52例乳癌组织冰冻切片进行免疫组织化学染色,观察TrfR在乳癌组织中的表达及其与临床病理特征的关系。结果显示:①TrfR阳性率为86.5%,它在癌组织中的表达以肿瘤浸润的边缘较中央略强,在细胞内表现为膜浆型;②TrfR在单纯癌及组织学Ⅲ级中表达较强;③TrfR在晚期病例、肿块>2cm者阳性率及强阳性率较高,在淋巴结转移组强阳性病例亦较多。提示TrfR的表达与肿瘤细胞的分裂增殖和侵袭力有关,具有一定的潜在预后价值。Transferrin receptor(TrfR) was immunocytochemically studied using a monoclonial antibody OKT_9 in primary breast carcinoma frozen sections of 52 cases and related to clinical pathological features. The results showed that 86.5% of the cases were TrfR positive which localized on the cell surface and in plasma. Receptor expression was most marked on the peripheral in vading margin of cancer cell island. Significant correlation was found between TrfR expression and histologic tumor type, grade of anaplasia, and also between TrfR and tumor size. It is suggested that TrfR expresion may correlate with cellular proliferation and invasion, and may be useful in prognosis of breast cancer.

关 键 词：免疫组织化学 乳腺癌 病理 

分 类 号：R737.902[医药卫生—肿瘤]