乳腺癌流式细胞光度术及临床病理与预后的关系  

The Relation between the Flow Cytometric and Clinic Pathologic Analysis of Breast Carcinomas and Their Prognosis

作　　者：李春华[1] 闫秀珍[1] 刘田福[2] 王琳娜[3] 刘育艳[4] 安小敏[1] 王晋芬[5] 郭日升[5] 徐欣[6] 王竞[6] 

机构地区：[1]山西医学院中心实验室细胞室,太原030001 [2]山西医学院科研处 [3]山西医学院预防医学系统计教研室 [4]山西医学院病理教研室 [5]山西省肿瘤医院病理科,太原030013 [6]北京医科大学分析计算中心,100083

出　　处：《临床与实验病理学杂志》1992年第2期106-109,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：对有随访资料的乳腺癌102例经流式细胞光度术测定及病理学检查,就乳腺癌细胞DNA含量、细胞周期时相分布、病理组织学分型、核分裂相数(M)、临床分类分期、肿瘤大小、年龄、术式、术后处理及癌旁病变等诸因素与术后生存期以及各因素间的关系做了统计学分析。结果显示DNA指数(DI)越高、DNA合成期细胞分数(S%)越大、临床分类分期越高,癌旁病变有癌变者及浸润型导管癌患者术后生存期均明显为短(P<0.01),手术方式以根治术效果好,术后生存期长(P<0.01);另外也显示DI值与S%间有明显相关性,异倍体组S%明显增高(P<0.05);S%越大、M数越大则肿瘤越大(P<0.05)。DNA index (102 cases) and cell cycle distribution(49 cases) of breast carcinoma cells were studied by flow cytometry. Histologic type,the number of mitoses, clinical stages, tumor size, age, operatic mode, treatment after operation and epithelial hyperplasia adjacent to breast carcinoma were observed. The results showed:all of the survival of the higher DT value, higher S% and the later clinical stage were evidently shorter (P<0.01). Survival patients with infiltrating ductal carcinomas was shorter than that of other tumor type (P<0.01). The survival of radical mastectomy was longer than that of other operatic modes (P<0.01). The value of S% of the aneuploid group was higher than that of the diploid and near—diploid group (P<0.05). The higher S% was the larger of the tumor size (P<0.05). The more number of mitoses was the larger the tumor size(P<0.05).

关 键 词：乳腺癌 NDA指数 病理 预后 

分 类 号：R737.902[医药卫生—肿瘤]