混合生物人工肝治疗肝衰竭临床疗效的初步评价  

Preliminary evaluation on the effects of a hybrid bioartificial liver support system in the treatment of hepatic failure

作　　者：王英杰[1] 何念海[1] 牛润章[1] 刘俊[1] 文红伟[1] 李嘉佳[1] 王宇明[1] 

机构地区：[1]重庆,第三军医大学西南医院,400038

出　　处：《中华肝脏病杂志》2003年第8期461-463,共3页Chinese Journal of Hepatology

基　　金：国家“九五”重点攻关项目(96-920-12-02);国家自然科学专项基金资助项目(30027001)

摘　　要：目的构建新型混合生物人工肝支持系统,初步评价其治疗肝衰竭的临床疗效. 方法用血浆置换装置、活性炭灌流器和培养人或猪肝细胞生物反应器构成混合型生物人工肝支持系统,对30例重型肝炎肝衰竭患者进行人工肝支持与治疗. 结果 30例患者人工肝支持治疗的显效率43.3%(13/30),有效率43.3%(13/30),总有效率86.7%.好转出院11例,成功等到肝移植6例,死亡6例,自动出院7例. 结论所建混合生物人工肝支持系统对肝衰竭有明显的肝支持作用,可作为重型肝炎的有效治疗手段.Objectives To construct a novel hybrid artificial liver support system and evaluate its clinical efficacy in the treatment of hepatic failure. Methods A hybrid bioartificial liver support system consisting of plasma exchange device, charcoal perfusion column, and bioreactor cultured human or porcine hepatocytes was developed. 30 patients with hepatic failure were treated using this hybrid system. Results Both the excellent rate and effectual rate of the artificial liver support system were 43.3% (13/30). The total effectual rate was 86.7%. Finally, eleven out of 30 patients recovered completely. Six patients were bridged to liver transplantation. Six patients (20%) died of hepatic failure and seven patients (23.3%) discharged due to worsening of disease. Conclusions The hybrid artificial liver support system has prominent liver support effects for hepatic failure, which can be regarded as an efficient measure for the treatment of severe hepatitis.

关 键 词：混合生物人工肝 治疗 肝衰竭 疗效评价 

分 类 号：R575.3[医药卫生—消化系统] R318.14[医药卫生—内科学]