肠易激综合征402例发病时间分布及症状特征  

Time cluster and symptom character of 402 outpatients with irritable bowel syndrome

作　　者：许小幸[1] 李定国[1] 朱光辉 周惠清[2] 刘清华[2] 

机构地区：[1]上海第二医科大学临床流行病学研究中心,上海市200092 [2]上海第二医科大学附属新华医院消化内科,上海市200092

出　　处：《世界华人消化杂志》2003年第8期1234-1236,共3页World Chinese Journal of Digestology

基　　金：上海市卫生局科技发展基金项目;No.01468

摘　　要：目的:了解肠易激综合征(irritable bowel syndrome,IBS)患者首次发病时间分布规律,为IBS进一步的病因研究提供线索。方法:对消化专科门诊就诊的符合罗马Ⅱ诊断标准的IBS患者402例进行问卷调查。对首次发病月份采用圆分布资料分析。结果:IBS患者的最长病程达54a,平均病程7.62a,男、女患者病程分布差别无显著性(x^2=2.35,P>0.05)。IBS患者发病有季节性,春季高发(Z=31.78,P<0.01),男性高发月份为3月份(Z=18.37,P<0.01),女性高发月份为4月份(Z=16.55,P<0.01),男、女性高发月份差别有显著性(t=3.32,P<0.01)。患者中腹泻型占36.6％,便秘型占18.4％,其他占45.0％,男、女亚型差别有显著性(x^2=7.77,P<0.05);腹痛是IBS最常见特征,腹痛部位以左下腹最多,其次为全腹痛,再次为右下腹痛,无单独的左上腹痛。结论:门诊IBS患者发病有季节高峰,季节可能是IBS发病的影响因素之一。AIM: To understand the time cluster regularity of the patients first caught by irritable bowel syndrome(IBS), and provide clue for further research on etiologic agents. METHODS: According to diagnostic criteria of Rome Ⅱ, 402 cases of TBS were investigated by questionnaire, and the onset month was analyzed with circular distribution. RESULTS: The longest course of IBS was 54 years, and the average course was 7.62 years. There was no difference between males and females in course distribution (x^2=2.35, P>0.05). IBS is a seasonal disease with high occurrences in spring (Z=31.78, P<0.01). Males had high occurrences in March (Z=18.37, P<0.01), however females in April (Z=16.55, P<0.01). There was a significant difference between male and female in the onset month. In IBS patients, diarrhea predominance accounted for 36.6 %, and constipation pre- dominance 18.4 %, and others 45.0 %. There was a sig- nificant difference in predominance between males and females (x^2=7.77, P<0.05). Abdominal pain was the most common symptom. CONCLUSION: IBS has seasonal occurrence, so season is probably one of the influential factors of IBS.

关 键 词：肠易激综合征 发病时间 时间分布 影响因素 季节 

分 类 号：R574.62[医药卫生—消化系统]