流行性感冒病毒裂解疫苗甲醛含量的探讨  

Study of the Formaldehyde Content of the Split Influenza Virus Vaccine

作　　者：陈列胜[1] 陈哲文[1] 金于兰[1] 蔡明勇[1] 陈菲[1] 秦洁[1] 

机构地区：[1]上海生物制品研究所,上海200052

出　　处：《中国计划免疫》2003年第4期230-232,共3页Chinese Journal of Vaccines and Immunization

摘　　要：为了探索流行性感冒 (流感 )病毒裂解疫苗中灭活剂甲醛的最适浓度 ,单价病毒液采用不同浓度的甲醛进行灭活后 ,分别跟踪测定单价病毒液和配制的疫苗液中血凝素 (HA)含量的变化。结果显示 :用 0 0 1%甲醛灭活的单价病毒液和配制的疫苗液 ,HA含量下降明显 ;用 0 0 0 4 %甲醛灭活的单价病毒液和配制的疫苗液 ,HA含量则较为稳定。提示流感疫苗宜采用较低浓度的甲醛进行灭活。This paper is to study the suitable concentration of formaldehyde used for inactivating split influenza virus vaccine.After monovalent virus bulk inactivated with different concentrations of formaldehyde,the haemagglutinin(HA)contents of both monovalent virus bulk and vaccine were tested respectively.The results showed that HA contents fell obviously by 0.01% formaldehyde inactivation,and HA contents were less changed by 0.004% formaldehyde inactivation.These data indicated that the lower concentration of formaldehyde is applicable for influenza vaccine.

关 键 词：流行性感冒病毒裂解疫苗 甲醛 含量 单价病毒液 血凝素 

分 类 号：R373.13[医药卫生—病原生物学] R392-33[医药卫生—基础医学]