普罗布可抗兔动脉成形术后再狭窄与调节血管重塑的关系  

Probucol prevents restenosis by regulating vascular remodeling after percutaneous transluminal angioplasty in rabbits

作　　者：杨云波[1] 廖端芳[1] 朱炳阳[1] 

机构地区：[1]南华大学药物药理研究所,湖南衡阳421001

出　　处：《中国病理生理杂志》2003年第9期1174-1177,T001,共5页Chinese Journal of Pathophysiology

基　　金：国家 973项目 (G2 0 0 0 0 5 6 90 5 );国家自然科学基金资助项目 (No .39970 84 7)

摘　　要：目的 :研究普罗布可抗动脉成形术后再狭窄与血管重塑的关系。方法 :用 3.5F球囊导管构建兔动脉粥样硬化动脉成形术后再狭窄模型 ,动脉成形术后 2周 ,观察普罗布可抗动脉成形术后再狭窄作用 ;组织形态学观察及计算机图像分析 ,了解普罗布可对病理性血管重塑的影响 ;血脂含量测定。结果 :普罗布可抗再狭窄作用显著 ,能明显增加血管内外径及管腔面积 ,减少新生内膜的形成 ;能调节血管重塑 ,增加动脉成形术后内弹力层包围的面积[IEL ,( 3.5 0± 0 .2 0 )mm2 vs ( 1.5 9± 0 .2 3)mm2 ,P <0 0 1]、外弹力层包围的面积 [EEL ,( 4 .6 1± 0 .2 9)mm2 vs ( 2 .5 6±0 .2 8)mm2 ,P <0 0 1];能调节血脂水平 ,降低血清总胆固醇及甘油三酯含量。结论 :普罗布可通过调节动脉成形术后血管病理性重塑达到抗再狭窄作用。AIM: To investigate the relationship between the prevention of probucol on restenosis and vascular remodeling after percutaneous transluminal angioplasty(PTA) in rabbits. METHODS: New Zealand rabbit thoracic aorta atherosclerosis was induced by 3.5F ballon catheter injury following a 4-weeks feeding of high cholesterol diet, and PTA was performed by using 3.5F balloon catheter. Probucol(1g/d) or vitamin E (400 mg/d) was administrated one week before PTA. Two weeks after PTA, the bore and outside diameter (OD) of arteries, the area circumscribing by intimal elastic lamina (IEL), the area circumscribing by extral elastic lamina (EEL), medial area (MA), neointima area/medial area (NEA/MA) were analyzed by computerized digitizer system. Lipids of serum were measured by means of biochemical assay.RESULTS: After two weeks of PTA, the intima proliferation and lumen restenosis were observed obviously. However, with probucol treatment for 3 weeks, the restenosis of aorta was inhibited significantly by increasing bore, outside diameter, and lumen area of rabbits aortas and decreasing NEA, NEA/MA. Furthermore, probucol regulated vascular remodeling by increasing the area circumscribing by IEL [(3.50±0.20)mm 2 vs (1.59±0.23) mm 2, P< 0 01 ] and EEL [(4.61±0.29) mm 2 vs (2.56±0.28) mm 2, P<0 01 ] of rabbit aortas. In addition, probucol decreased lipids of serum in rabbits. CONCLUSION: Probucol prevents restenosis by regulating vascular remodeling after percutaneous transluminal angioplasty in rabbits.

关 键 词：普罗布可 血管成形术 再狭窄 血管重塑 

分 类 号：R363[医药卫生—病理学]