基因多态性与化学物致病风险  

Genetic polymorphism and risk of diseases induced by chemicals

作　　者：张忠彬[1] 夏昭林[1] 

机构地区：[1]复旦大学公共卫生学院劳动卫生教研室,上海200032

出　　处：《卫生研究》2003年第4期402-405,共4页Journal of Hygiene Research

基　　金：国家自然科学基金资助项目(No.30 2 71113)

摘　　要：个体对外源性化学物的反应因其基因DNA序列的多态性而有所不同 ,这些多态性可影响机体对化学物的易感性 ,进而影响到个体发病风险的差异。The response of the individuals to xenobiotics is various due to the genetic polymorphism, that is, most likely, the determinant factor of the susceptibility of the individuals to xenobiotics. Therefore, the risk of diseases taking cancers as an example is different in population. In this paper, progresses of genetic polymorphism of toxicant metabolizing enzyme genes and DNA repair genes and, their effects on individuals' risk to diseases were briefly reviewed.

关 键 词：基因多态性 毒物代谢酶 DNA损伤修复 化学物 发病风险 

分 类 号：R394[医药卫生—医学遗传学]