KAI1/CD82在大肠肿瘤中的表达  

Expression of KAI1/CD82in human colorectal tumor

作　　者：吴德华[1] 刘莉[2] 陈龙华[1] 丁彦青[2] 

机构地区：[1]第一军医大学南方医院放疗科,广东广州510515 [2]第一军医大学病理学教研室,广东广州510515

出　　处：《第一军医大学学报》2003年第7期714-715,719,共3页Journal of First Military Medical University

基　　金：广东省自然科学基金(990385)~~

摘　　要：目的探讨KAI1/CD82在大肠肿瘤的表达及意义。方法选取40例大肠癌、20例淋巴结转移癌、18例腺瘤与20例正常大肠粘膜标本,应用免疫组化检测KAI1的蛋白产物CD82的表达。结果正常大肠粘膜与腺瘤组织CD82表达较弱(阳性率分别为25.0%与5.6%),大肠癌组织中28例阳性,阳性率为70 %,淋巴结转移癌阳性率为5%,4组之间的差异有统计学意义(P<0.05)。CD82在肿瘤组织中的表达与其组织学分级无关(P>0.05),而与是否伴有淋巴结转移有关(P<0.05)。结论KAI1/CD82与大肠癌转移及预后相关。Objective To study the expression of KAI1/CD82 in human colorectal tumor and its significance. Methods Im-munohistochemistry was used to detect the expression of CD82 in 40 colorectal carcinoma, 20 lymphatic metastasis, 18 ade-noma and 20 normal colorectal epithelium specimens, respectively. Results The expression of CD82 was rather low in adeno-ma and normal colorectal epithelium, with the positivity rates of 25% and 10% respectively; 28 of the 40 colorectal carcinoma specimens were positive for CD82, resulting in a positivity rate of 70%. The rate for lymphatic metastasis was only 5%. The differences between the 4 groups were significant (P<0.05), and the expression of CD82 in the carcinoma was not related to the histological grades (P>0.05), but was associated with the presence of metastasis (P<0.05). Conclusion CD82 is related to the progression of colorectal carcinoma.

关 键 词：大肠肿瘤 KAIL/CD82 基因表达 肿瘤转移 免疫学 

分 类 号：R735.34[医药卫生—肿瘤]