VEGF、VEGF-C、flt-4在乳腺癌组织中的表达及临床病理分析  

Expression of vascular endothelial growth factors VEGF, VEGF-C and flt-4 in breast cancer and its clinical pathological analysis

作　　者：刘毅[1] 崔杰[1] 张俊坤[1] 曹道成[1] 后强[1] 张世和[1] 赵仲伟[1] 叶晓霞[2] 石岚[2] 

机构地区：[1]安徽省马钢(集团)控股有限公司医院普外科,安徽马鞍山243000 [2]安徽省马钢(集团)控股有限公司医院病理科,安徽马鞍山243000

出　　处：《中国癌症杂志》2003年第4期326-328,共3页China Oncology

摘　　要：目的:探讨乳腺癌组织中VEGF、VEGF-C、flt-4蛋白的表达水平、相互关系及临床意义。方法:采用免疫组织化学ABC法,检测82例乳腺癌石蜡标本中VEGF、VEGF-C、flt-4蛋白的表达水平。结果:乳腺癌标本中VEGF、VEGF-C、flt-4蛋白的阳性表达率分别为57.3％、46.3％、50.0％,VEGF-C与flt-4蛋白的表达呈正相关。但与乳腺癌组织病理学分型、肿瘤大小和分级无关。结论:VEGF-C、flt-4蛋白的表达与乳腺癌淋巴结转移有关,并可能协同作用于淋巴结转移过程。Purpose: To study the expression of VEGF, VEGF-C, fit-4 in breast cancer and its relationship with lymph node metastasis and explore the significance of lymphangiogenesis on metastasis via lymphtics. Methods: Paraffin-embedded specimens from 82 patients with primary breast cancer who had undergone radical mastectomy with lymph node dissection were studied. VEGF, VEGF-C, flt-4 expression were investigated by immunohistochemical staining. Results: Positive staining for VEGF, VEGF-C, flt-4 were observed in some breast cancer cells. Furthermore, the expression of VEGF-C, flt-4 were significantly higher in lymph node-positive group than in node-negative group. Correlation was found within the expression of VEGF-C, flt4 also. Conclusions: Clinical significance was found between VEGF-C, flt-4 expression and lymph-node metastasis in breast cancer, and may be involved in the metastatic process.

关 键 词：VEGF VEGF-C fit-4 乳腺癌 表达 病理分析 癌组织 

分 类 号：R737.9[医药卫生—肿瘤]