趋化性细胞因子与乳腺癌的转移  

Chemokine and breast cancer metastasis

作　　者：姚晓英[1] 宋晖[1] 李大金[1] 

机构地区：[1]复旦大学妇产科医院妇产科研究所,上海,200011

出　　处：《中国癌症杂志》2003年第4期381-384,共4页China Oncology

摘　　要：远处转移是乳腺癌致死和预后较差的重要原因,而在乳腺癌转移中,趋化性细胞因子扮演着重要角色,乳腺癌细胞高表达某些趋化性细胞因子及某些受体,通过趋化性细胞因子与其受体的相互作用,趋化吞噬细胞及淋巴细胞浸润,促使癌细胞侵入正常组织及血管生成,形成转移肿瘤。本文主要综述了近年研究较多的趋化性细胞因子受体CXCR4及趋化性细胞因子RANTES、IL-8、MCP-1等在乳腺癌转移中的作用。Breast cancer metastasis is the main cause of tumor death and poor long-term effect in clinical treatment. In the process of metastasis, chemokine may play the main role. In the breast cancer cell, some chemokine and receptor were expressed excessively. It has been shown that through the interaction between chemokine and correspondence receptor, phagocyte and lymphocyte infiltration stimulated, tumor cell invasion into normal tissue with angiogenesis, thus the metastasis was formed. This article reviews the mechanisms of chemokine receptor CXCR4 and chemokine RANTES ,IL-8 MCP-1 in breast cancer metastasis.

关 键 词：趋化性细胞因子 乳腺癌 转移 趋化性细胞因子受体 

分 类 号：R737.9[医药卫生—肿瘤]